1 ‘Mark Kac’ Complex Systems Research Centre, Uniwersytet Jagielloński, ul. Reymonta 4, 30-059 Kraków, Poland 2 Fachbereich Physik, Universität Duisburg-Essen, Campus Duisburg, 47048 Duisburg, Germany 3 Instytut Fizyki im. Smoluchowskiego, Uniwersytet Jagielloński, ul. Reymonta 4, 30-059 Kraków, Poland 4 Centrum Fizyki Teoretycznej, Polska Akademia Nauk, Al. Lotników 32/44, 02-668 Warszawa, Poland

Introduction Listeriosis is a food-borne disease which primarily affects people in particular risk-groups (immuno-suppressed, elderly, neonates) in which lethality is as high as 25%. The disease does occur in out-breaks but most cases appear as sporadic cases. The disease is primarily associated with ready-to-eat (RTE) food products with extended (refrigerated) shelf life. Outbreaks have mostly...

Valerio Cappellini1,2, Hans-Jürgen Sommers3 and Karol Życzkowski1,4 Centrum Fizyki Teoretycznej, Polska Akademia Nauk, Al. Lotników 32/44, 02-668 Warszawa, Poland 2“Mark Kac” Complex Systems Research Centre, Uniwersytet Jagielloński, ul. Reymonta 4, 30-059 Kraków, Poland 3Fachbereich Physik, Universität Duisburg-Essen, Campus Duisburg, 47048 Duisburg, Germany 4Instytut Fizyki im. Smoluchowskieg...

Dr. M. G. Willinger Department of Inorganic Chemistry Fritz Haber Institute of the Max Planck Society Berlin, 14195, Germany Prof. A. G. Checa Departamento de Estratigrafía y Paleontología Universidad de Granada Granada, 18071, Spain E-mail: [email protected] Prof. J. T. Bonarski, Prof. M. Faryna, Dr. K. Berent Institute of Metallurgy and Materials Science of the Polish Academy of Sciences Kraków, ...

1: M. Smoluchowski Institute of Physics, Jagiellonian University, PL–30–059 Cracow, Poland 2: Mark Kac Center for Complex Systems Research, Jagiellonian University, PL–30–059 Cracow, Poland 3: University of Winnipeg, Winnipeg, Manitoba, Canada 4: Alberta Innovates, Winnipeg, Manitoba, Canada 5: Thunder Bay Regional Research Institute, Thunder Bay, Ontario, Canada Institute of Nuclear Physics, P...

BACKGROUND AND PURPOSE NXY-059 is a nitrone-based free radical-trapping agent in development for acute stroke. In patients with acute stroke, NXY-059 is well tolerated at concentrations known to be associated with neuroprotection in animal models of transient cerebral ischemia; however, higher target concentrations appear necessary on the basis of animal models of permanent ischemia. METHODS ...

BACKGROUND AND PURPOSE The neutral results of the SAINT II trial have again highlighted difficulties translating neuroprotective efficacy from bench to bedside. Animal studies are susceptible to study quality biases, which may lead to overstatement of efficacy. We report the impact of study quality on published estimates of the efficacy of NXY-059 in animal models of stroke. METHODS We conduc...

The SAINT studies on NXY-0591,2 have reinvigorated debate over the momentous issues of neuroprotection and the development of novel stroke therapeutics. Some may argue there is little new ground that NXY-059 has unearthed and, in fact, the clinical trials merely confirm that as a strategy, neuroprotection has not been shown to be effective. Editorials in high-profile journals have sent out the ...