The characterisation of the risk of (new) chemicals to species/communities, when both the exposure/environmental concentration and effects (species sensitivity) are variable and uncertain, is the central issue in Probabilistic Environmental Risk Assessment. The spatial variability is one of the largest components of the total variability. This paper tries to explicitly account for this spatial ...

Preface This manuscript contains my personal and informal notes on the probabilistic method as it is applied in graph theory. It hasn't been properly proofread , and it is by no means intended for wider distribution. For an introduction to the probabilistic method, I refer the reader to the textbooks mentioned in the bibliography. I'm very grateful for the assistance and advice I have received ...

The cardiac conduction system (CCS) consists of distinctive components that initiate and conduct the electrical impulse required for the coordinated contraction of the cardiac chambers. CCS development involves complex regulatory networks that act in stage-, tissueand dose-dependent manners, and recent findings indicate that the activity of these networks is sensitive to common genetic variants...

1 Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands 2 Department of Clinical Neurophysiology and Magnetoencephalography Centre, VU University Medical Centre, Amsterdam, The Netherlands 3 Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands 4 Department of Clinical Epidemiology and Biostatistics, VU Unive...

Many amyloid inhibitors resemble molecules that form chemical aggregates, which are known to inhibit many proteins. Eight known chemical aggregators inhibited amyloid formation of the yeast and mouse prion proteins Sup35 and recMoPrP in a manner characteristic of colloidal inhibition. Similarly, three known anti-amyloid molecules inhibited b-lactamase in a detergent-dependent manner, which sugg...

women than in men. These conditions are the most common psychiatric illnesses diagnosed in children, adolescents, and older adults. Anxiety disorders may significantly affect a patient’s quality of life and overall health. Anxiety is commonly associated with depression, other mood disorders, and substance abuse. Numerous potentially life-threatening medical disorders feature symptoms that often...

The mechanisms of excessive sputum production are only partially understood. We speculated that a selective thromboxane (Tx) A2 synthetase inhibitor, OKY-046, now used in the treatment of asthma in Japan, could decrease excess sputum production in patients with chronic airways disease. To test this hypothesis, we carried out a double-blind, placebo-controlled study of the effects of OKY-046, ad...

Cyclooxygenase products are released by chronic airway inflammation. Our working hypothesis for the present study was that prostanoids augment airway cough sensitivity. The effects of a cyclooxygenase inhibitor, indomethacin (100 mg.day-1 for 4 days), and a thromboxane synthesis inhibitor, OKY-046 (400 mg.day-1 for 4 days), on cough response to inhaled capsaicin were examined in eight patients ...