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OBJECTIVE Myostatin is an endogenous negative regulator of muscle growth and a novel target for muscle diseases. We conducted a safety trial of a neutralizing antibody to myostatin, MYO-029, in adult muscular dystrophies (Becker muscular dystrophy, facioscapulohumeral dystrophy, and limb-girdle muscular dystrophy). METHODS This double-blind, placebo-controlled, multinational, randomized study...
Murine T cell epitopes against vaccinia virus (VV) have not been characterized to date in part due to the large and complex genome of VV. We have identified and characterized two CD8+ T cell epitopes on the A47L (modified VV Ankara strain (MVA)-029) and J6R (MVA-043) proteins of VV that are Db and Kb restricted, respectively. Following i.p. immunization with VV New York City Board of Health (NY...
Colorectal carcinoma cells Isreco1 display an ability to migrate controlled by a complex set of signals issued from the membrane. By comparing cells infected by mycoplasmas and mycoplasmas free cells, we have established that basal 2D migration is dependent on a double signal mediated by the collagen receptors integrins alpha1/2 and the Toll-Like receptor TLR2. The signal issued from mycoplasma...
We analyze classical and quantum chiral ring relations of four dimensional N = 1 adjoint SQCD with superpotential turned on for the adjoint field. In particular, for the mass deformed theory we obtain the complete on shell vacuum expectation value for various gauge invariant chiral operators and find non-trivial gaugino condensations. When approaching to massless limit nontrivial flat direction...
Methods We studied consecutive FMF patients, who came for a pre-scheduled follow up visit in the FMF clinic for the presence of microscopic hematuria, defined as ≥5 RBC/HPF or ≥25RBC/μl in urine analysis performed during remission, recorded at least once in the 3 previous clinic visits. Exclusions were known kidney, urinary tract, prostate or gynecologic diseases, bleeding or thrombotic diathes...
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C l i n M e d International Library Citation: Mohammed SB, Gadad A, Nayak BS, Beharry V (2016) Prognosis of the MidlifeElderly from ECG Testing to Gastroesophageal Reflux Disease and Coronary Artery Disease. J Fam Med Dis Prev 2:029 Received: December 24, 2015: Accepted: March 29, 2016: Published: April 01, 2016 Copyright: © 2016 Mohammed SB, et al. This is an open-access article distributed un...
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