Abstract Introduction Sleep irregularity has been associated with worse cardio-metabolic health compared to regular sleep, but prior studies have limited in sample size and assessed sleep by actigraphy or questionnaires over a relatively short duration (~ 14 days). The current study investigated associations between regularity hypertension large, global multiple months. Methods Data from 12,300...

A wheel is a graph formed by a chordless cycle C and a vertex u not in C that has at least three neighbors in C. We prove that every 3-connected planar graph that does not contain a wheel as an induced subgraph is either a line graph or has a clique cutset. We prove that every planar graph that does not contain a wheel as an induced subgraph is 3-colorable. AMS classification: 05C75 ∗Partially ...

Boltzmann models from statistical physics, combined with methods from analytic combinatorics, give rise to efficient and easy-to-write algorithms for the random generation of combinatorial objects. This paper proposes to extend Boltzmann generators to a new field of applications by uniformly sampling a Hadamard product. Under an abstract real-arithmetic computation model, our algorithm achieves...

Typhoid, caused by Salmonella typhi, has been the most common human illness. In the present study, peptide-based subunit vaccine was developed from OMPLA and LsrC against S. typhi. We adopted sequence, 3-D structure and fold level in silico analysis to predict B-cell and T-cell epitopes. The 3-D structure was determined for OMPLA and LsrC by homology modeling and the modeled structure was valid...

Cytotoxic T cells recognize specific peptides bound to major histocompatibility complex (MHC) class I molecule. Accurate prediction for the binding peptides could be of much use for the design of efficient peptide vaccines, which substantially reduce the cost of synthesizing and testing candidate binders. In this paper, we demonstrated that a machine learning approach can be successfully applie...

Due to diverse architectures in deep neural networks (DNNs) with severe overparameterization, regularization techniques are critical for finding optimal solutions the huge hypothesis space. In this paper, we propose an effective technique, called Neighborhood Region Smoothing (NRS). NRS leverages that models would benefit from converging flat minima, and tries regularize neighborhood region wei...

This paper examines the distributional implications of mandatory longevity insurance when there is mortality heterogeneity in the population. Previous research has demonstrated the significant financial redistribution that occurs under alternative annuity programs in the presence of differential mortality across groups. This paper embeds that analysis into a life cycle framework that allows for...

Modernization is not only in the field of electronics, but also transportation. As a result this modernization, many young people, especially children, are affected. The role parents to monitor growth and development child very much expected living life era modernization. In case file Number: BP/01/I/2017/Traffic. Police Report LP/0204/244/XII/2016/LL contains traffic accident crime committed b...