نتایج جستجو برای: کلیدواژهها د 503

تعداد نتایج: 9326  

2017
Jun Ikari Amy J Nelson Jannah Obaid Alvaro Giron-Martinez Kumiko Ikari Fumihiko Makino Shunichiro Iwasawa Yoko Gunji Maha Farid Xingqi Wang Hesham Basma Dawn Demeo Carol Feghali-Bostwick Olaf Holz Klaus Rabe Xiangde Liu Stephen I Rennard

Alterations in microRNA (miRNA) expression may contribute to COPD pathogenesis. In COPD, lung fibroblast repair functions are altered in multiple ways, including extracellular mediator release. Our prior study revealed miR-503 expression is decreased in COPD lung fibroblasts, although the exact role played by miR-503 is undetermined. The current study examined a role of miR-503 in cytokine, gro...

Journal: :International journal of clinical and experimental medicine 2015
Hao Liu Zhi Song Daguang Liao Tianyi Zhang Feng Liu Wen Zheng Kui Luo Liang Yang

Deregulated microRNAs and their roles in tumorigenesis have attracted much attention in recent years. Although miR-503 has been reported to be aberrant expression in several cancers, its role in glioma remains unknown. In this study, we focused on the expression and mechanisms of miR-503 in glioma development. We found that miR-503 was downregulated in glioma cell lines and tumor tissues, and t...

2014
YINGYING ZHANG XIONG CHEN HAIWEI LIAN JIANMIAO LIU BEIYAN ZHOU SONG HAN BIWEN PENG JUN YIN WANHONG LIU XIAOHUA HE

microRNA (miRNA) dysregulation is associated with various types of human cancer by regulating cancer cell survival, proliferation and invasion. Aberrant expression of microRNA-503 (miR-503) has been reported in several cancer profiles. However, potential linkage of miR-503 levels and the underlying regulatory mechanisms in human glioblastoma multiforme (GBM) remain unclear. In the present study...

2017
Daoyi Wu Gaojian Cao Zhenfeng Huang Kai Jin Haowei Hu Jie Yu Yu Zeng

BACKGROUND Altered expression of miR-503 has been linked to human carcinogenesis. In this present study, we aimed to detect the potential for miR-503 as a novel biomarker for gastric cancer (GC) patients. MATERIALS AND METHODS The relative mRNA level of miR-503 in serum and tissue of 68 GC patients and serum of 32 healthy volunteers was determined by real-time reverse transcription quantitati...

Journal: :Circulation 2011
Andrea Caporali Marco Meloni Christine Völlenkle Desiree Bonci Graciela B Sala-Newby Roberta Addis Gaia Spinetti Sergio Losa Rachel Masson Andrew H Baker Reuven Agami Carlos le Sage Gianluigi Condorelli Paolo Madeddu Fabio Martelli Costanza Emanueli

BACKGROUND Diabetes mellitus impairs endothelial cell (EC) function and postischemic reparative neovascularization by molecular mechanisms that are not fully understood. microRNAs negatively regulate the expression of target genes mainly by interaction in their 3' untranslated region. METHODS AND RESULTS We found that microRNA-503 (miR-503) expression in ECs is upregulated in culture conditio...

2017
Lanfang Jiang Zitong Zhao Leilei Zheng Liyan Xue Qimin Zhan Yongmei Song

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers in China, but the underlying molecular mechanism of ESCC is still unclear. Involvement of microRNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human cancers, its detailed anti-oncogenic role and clinical significance in ESCC remain undefined. In th...

2017
Jingwang Yan Yonghuan Xu Haipeng Wang Taiping Du Hao Chen

MicroRNAs (miRs), a class of non-coding RNAs that are 18‑25 nucleotides in length, serve as key regulators in the development and progression of human cancers. Previously, miR‑503 has been implicated in breast cancer. However, the underlying mechanism of miR‑503 in regulating the proliferation and invasion of breast cancer cells remains largely unknown. In the present study, reverse transcripti...

Journal: :Molecular medicine reports 2015
Bing Wu Wenzhi Bi

The present study aimed to investigate the expression levels of microRNA (miR)‑503 in osteosarcoma (OS), as well as to assess the effects and underlying mechanisms of miR‑503 on cell proliferation, apoptosis, migration and invasion of OS cells. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to determine the expression levels of miR‑503 in OS and adjacent normal ...

2017
Yu Shuang Xuan Zhou Chao Li Yongwang Huang Lun Zhang

Laryngeal squamous cell carcinoma (LSCC), the most common form of laryngeal carcinoma, is an aggressive malignancy that demonstrates the second highest rate of morbidity of all head and neck squamous cell carcinomas. The abnormal expression of microRNAs (miRs) has been demonstrated in a number of types of human cancer, and they have been demonstrated to be oncogenes or tumour suppressor genes. ...

2013
Saori Horiuchi Vachel Gay V. Paller Shoji Uga

Infectious diseases caused by soil-transmitted helminths (STHs) are important diseases of humans, which affect about one third of the world’s population. Examination of soil can be used to estimate the risk of STH infection in humans. We carried out this survey to clarify the current status of soil contamination by parasite eggs and to assess the risk of STH infection. During survey periods, we...

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