OBJECTIVE Recently, new treatment options for rheumatoid arthritis (RA) patients with an inadequate response to methotrexate (MTX) have become available. Given the wide variability in efficacy and costs among these different treatment options, we sought to determine their cost-effectiveness (CE) in order to guide policy in different cost-constrained settings. METHODS We performed a CE analysi...

Acrolein (Acr), a ubiquitous environmental contaminant, is a human carcinogen. Acr can react with DNA to form mutagenic α- and γ-hydroxy-1, N(2)-cyclic propano-2'-deoxyguanosine adducts (α-OH-Acr-dG and γ-OH-Acr-dG). We demonstrate here that Acr-dG adducts can be efficiently repaired by the nucleotide excision repair (NER) pathway in normal human bronchial epithelia (NHBE) and lung fibroblasts ...

BACKGROUND The purpose of this study is to evaluate the relationship between American College of Radiology (ACR) in-training examination scores and performance on the Royal College of Physicians and Surgeons of Canada (RCPSC) radiology licensing examination. METHODS Percentile ACR examination scores for 67 residents were obtained from 1995 to 2011 for four years of training and compared with ...

Background: The purpose of this study is to evaluate the relationship between American College of Radiology (ACR) in-training examination scores and performance on the Royal College of Physicians and Surgeons of Canada (RCPSC) radiology licensing examination. Methods: Percentile ACR examination scores for 67 residents were obtained from 1995 to 2011 for four years of training and compared with ...

OBJECTIVES Acrylamide (ACR) has many applications in different industries. ACR damages the central and the peripheral nervous system in human and animals. Importance of ACR-induced neurotoxicity encouraged researchers to find both different mechanisms involved in ACR neurotoxicity and potent neuroprotective agents. Therefore, this study was designed to investigate the protective effect of croci...

Methods 30 children with JIA were treated with ABA. 23 (77%) pts had polyarticular course of JIA and 7 (23%) systemic JIA. 11 children were diagnosed with acute uveitis (totally 14 affected eyes). 28 (93%) of pts were female. All patients had high degree (III) of disease activity. Mean disease duration was 6,1 ± 3,2 yr. 29 patients previously had an inadequate response to 2 or more non-biologic...

Acetylcholine (ACh) receptors (AChR) regulate neural circuit activity in multiple contexts. In humans, mutations in ionotropic acetylcholine receptor (iAChR) genes can cause neurological disorders, including myasthenia gravis and epilepsy. In Caenorhabditis elegans, iAChRs play multiple roles in the locomotor circuit. The cholinergic motor neurons express an ACR-2-containing pentameric AChR (AC...

OBJECTIVE To determine how often the Ambulance Call Record (ACR) was available to emergency department (ED) physicians and whether it contained information that changed the ED management of patients. METHODS This was a prospective cohort study of adult patients transported to one of two tertiary care centre EDs. Physicians completed a data collection form for each patient regarding ACR availa...

acrolein (acr) is α, β unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. it can also be generated through endogenous metabolism. the aim of this study was to investigate the possible protective role of pentoxifylline (ptx) is a non-selective phosphodiesterase (pde) inhibitor on toxicity of acr. in this study, oxidative damage were measured by marke...