Reaction of 2-hydrazinocarbonyl-3-chloro-5-phenoxy-benzo[b] thiophene with different substituted phenyl isothiocyanate gave N-substituted arylthiosemi-carbazide derivatives (1a-h). 1,3,4-Thiadiazole derivatives (2a-h) were prepared by the cyclization of arylthiosemicarbazides (1a-h) with concentrated sulphuric acid. All the compounds were screened for their antitubercular activity against Mycob...

background despite significant advances in the treatment of chronic hepatitis c in the past decades, factors which can affect response rates to combination therapy; peginterferon and ribavirin, are still under study and reaching sustained virological response (svr) is affected by several different factors. objectives to investigate predictor factors contributing to svr in iranian patients. pati...

background: hepatitis c is a disease with significant global impact. the distribution of hepatitis c virus (hcv) genotypes in mashhad (the northeast and the biggest city after the capital of iran) is unknown. the purpose of this study was to determine the prevalence of hcv genotypes among hcv seropositive patients, and to study the relationship between types, virologic and demographic features ...

isoxazole (2a-l) and cyanopyridine (3a-l) derivatives have been prepared by condensing chalcones (1a-l) with hydroxylamine hydrochloride and malononitrile respectively. while compounds 1a-l have been synthesized by the reaction of p-(3’-chloro-2’-benzo(b)thiophenoylamino)-acetophenone with different aldehydes. all the compounds were screened for their antitubercular and antimicrobial activities...