نتایج جستجو برای: ژن pten

تعداد نتایج: 25032  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده علوم 1386

چکیده ندارد.

Journal: :iranian biomedical journal 0
ایثار نصیری issar nassiri مهری فقیهی mehri faghihi منوچهر توسلی manoochehr tavassoli

background: pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. breast cancer is one of the most common cancers among women worldwide. treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic p...

ژورنال: :مجله علوم پزشکی رازی 0
بیتا فام bita faam research institute for endocrine sciences, shahid beheshti university of medical scienceپژوهشکده علوم غدد درون ریز و متابولسم دانشگاه شهید بهشتی فاطمه امام fatemeh emam research institute for endocrine sciences, shahid beheshti university of medical scienceپژوهشکده علوم غدد درون ریز و متابولسم دانشگاه شهید بهشتی محمد علی غفاری mohammad ali ghaffari research institute for endocrine sciences, shahid beheshti university of medical scienceپژوهشکده علوم غدد درون ریز و متابولسم دانشگاه شهید بهشتی فریدون عزیزی fereidoun azizi research institute for endocrine sciences, shahid beheshti university of medical scienceپژوهشکده علوم غدد درون ریز و متابولسم دانشگاه شهید بهشتی

یکی از عوامل مؤثر در توموری شدن سلول ها، تغییر الگوی اپی ژنتیک است. فرآیندهای اپی ژنتیک به ویژه الگوی غیرطبیعی متیلاسیون ژن ها در سرطان های تیروئید نقش مهمی دارند و افزایش متیلاسیون در نواحی تنظیمی بسیاری از ژن های سرکوب کننده تومور از جمله pten، rassf1a timp3 و در نتیجه خاموش شدن آن ها در این نوع سرطان گزارش شده است. با توجه به اختصاصی بودن الگوی متیلاسیون ژن ها در انواع سلول های توموری، احتما...

Issar Nassiri, Manoochehr Tavassoli, Mehri Faghihi,

Background: Pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. Breast cancer is one of the most common cancers among women worldwide. Treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic p...

Journal: :middle east journal of cancer 0
nasrollah erfani cancer immunology group, shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran mohammad javad fattahi cancer immunology group, shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran mohammad hossein dabbaghmanesh endocrinology and metabolism research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran mohammad mehrazmay cancer immunology group, shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran ahmad monabati department of pathology, school of medicine, shiraz university of medical sciences, shiraz, iran akbar rasekhi kazerouni endocrinology and metabolism research center, nemazee hospital, shiraz university of medical sciences, shiraz, iran

background: the phosphatidylinositol 3-kinase/akt signaling pathway is recognized as a key driver of cancer cell survival and proliferation, and is often contingent upon an impairment of expression/function of the pten tumor suppressor, a negative regulator of this pathway. in addition, the cytoskeletal signaling protein tensin 2 has also been implicated as a negative regulator of this pathway....

Journal: :International Journal of Human Genetics 2022

The purpose of this study was to explore the correlations arterial-phase enhanced CT characteristics hepatocellular carcinoma (HCC) with differentiation degree and expressions proliferating cell nuclear antigen (PCNA) phosphatase tensin homologue (PTEN). Seventy-nine HCC patients who underwent three-phase dynamic contrast-enhanced before surgery were selected observe characteristics. tissue eva...

Journal: :journal of cell and molecular research 0
hajar aryan zahra-soheila soheili

there exists an association between pi3k pathway licentious activity and the considerable feature of high metastatic potential of the genitourinary cancer cells. although du 145 and 5637 have functional phosphatase and tensin homolog (pten) tumor suppressor gene, which antagonizes pi3k function, pc-3 is null for pten gene. in pursuit to explain why pten bearing cell lines display high metastati...

Journal: : 2023

Aim: Prostate cancer is the second leading cause of death in cancer-related deaths men. Docetaxel and abiraterone acetate are widely used treatment castration-resistant metastatic prostate cancer. Phospho-PTEN triggers proliferation, migration, angiogenesis survival cells by causing oncogenic Akt hyperactivation. This study, it aimed to investigate effects docetaxel agents, which cancer, on exp...

Journal: :Biological & Pharmaceutical Bulletin 2021

Gastric cancer is one of the most common malignancies with a high mortality rate world. This study intends to make clear role and mechanism Scutellarin (Scu), flavonoid isolated from Erigeron breviscapus (Vant.) Hand.-Mazz, in regulating evolvement gastric cancer. We selected different doses Scu treat cells (MGC-803 AGS). Then, cell counting kit-8 (CCK8) assay was conducted verify proliferation...

Journal: :Genes and Diseases 2023

Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene has role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3) into 4,5-bisphosphate (PIP2). The function of PTEN regulated different mechanisms inactive results aggressive phenotype tumorigenesis. Identifying targeted therapies for genes such as been challenging it d...

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