Aim The goal of this paper is to introduce a perspective view the formation and application evidence-based management approach investigators, managers policymakers as how different determinants managerial-decision processes can be more effectively linked for salient healthcare organizations. Methods a...

Background: IgE and IgG4 are implicated in atopic development clinically utilized as major biomarkers. Atopic responses following certain pathogens, such Porphyromonas gingivalis (Pg), are currently an area of interest for further research. The aim this study is to measure the level IgE, IgG<ns3:sub...

Flaviviral NS3 is a multifunctional protein displaying N-terminal protease activity in addition to C-terminal helicase, nucleoside 5'-triphosphatase (NTPase), and 5'-terminal RNA triphosphatase (RTPase) activities. NS3 is held to support the separation of RNA daughter and template strands during viral replication. In addition, NS3 assists the initiation of replication by unwinding the RNA secon...

Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. The HCV RNA genome is translated into a single polyprotein. Most of the cleavage sites in the non-structural (NS) polyprotein region are processed by the NS3/NS4A serine protease. The vital NS2-NS3 cleavage is catalyzed by the NS2 autoprotease. For efficient processing at the NS2/NS3 site, the NS2 cysteine protease...

BACKGROUND Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viperin, and interleukin 28whichare important proteins in antiviral response. OB...

The hepatitis C virus (HCV) NS3 protease cleaves the viral polyprotein at specific sites to release the putative components of the HCV replication machinery. Selective inhibition of this enzyme is predicted to block virus replication, and NS3 is thus considered an attractive candidate for development of anti-HCV therapeutics. To set up a system for analysis of NS3 protease activity in cultured ...

Background: Photocatalytic air purifiers based on nano-titanium dioxide (TiO2) visible light activation provide an efficient solution for removing and degrading contaminants in air. The potential detachment of TiO2 particles from the purifier to indoor could cause a safety concern. A release was measured one commercially availabl...

Background: Plant products, including seeds are an important source of vitamins, minerals, proteins, and energy. This study aimed to assess parasitic contaminations in roasted groundnuts, nabag, tasali (watermelon seeds) sold by street vendors Khartoum State, Sudan. Methods: The frequency among all crop products was ...

The N-terminal amphipathic helix α(0) of hepatitis C virus (HCV) NS3 protein is an essential structural determinant for the protein membrane association. Here, we performed functional analysis to probe the role of this helix α(0) in the HCV life cycle. A point mutation M21P in this region that destroyed the helix formation disrupted the membrane association of NS3 protein and completely abolish...

Chronic infection with hepatitis C virus (HCV) affects 130 million people worldwide and is a major cause of liver cirrhosis and liver cancer. After translation of the HCV RNA genome into a polyprotein, 2 viral proteases process its non-structural protein (NS) region. While the essential chymotrypsin-like serine protease NS3-4A mediates all cleavages downstream of NS3, the NS2-3 cysteine proteas...