نتایج جستجو برای: ژن hdac4

تعداد نتایج: 16335  

Journal: :Molecular biology of the cell 2006
Fang Liu Nabendu Pore Mijin Kim K Ranh Voong Melissa Dowling Amit Maity Gary D Kao

Histone deacetylases mediate critical cellular functions but relatively little is known about mechanisms controlling their expression, including expression of HDAC4, a class II HDAC implicated in the modulation of cellular differentiation and viability. Endogenous HDAC4 mRNA, protein levels and promoter activity were all readily repressed by mithramycin, suggesting regulation by GC-rich DNA seq...

Journal: :Molecular biology of the cell 2004
Gabriela Paroni Michela Mizzau Clare Henderson Giannino Del Sal Claudio Schneider Claudio Brancolini

Histone deacetylases (HDACs) are important regulators of gene expression as part of transcriptional corepressor complexes. Here, we demonstrate that caspases can repress the activity of the myocyte enhancer factor (MEF)2C transcription factor by regulating HDAC4 processing. Cleavage of HDAC4 occurs at Asp 289 and disjoins the carboxy-terminal fragment, localized into the cytoplasm, from the ami...

Journal: :EMBO reports 2014
Moon-Chang Choi Soyoung Ryu Rui Hao Bin Wang Meghan Kapur Chen-Ming Fan Tso-Pang Yao

During muscle regeneration, the transcription factor Pax7 stimulates the differentiation of satellite cells (SCs) toward the muscle lineage but restricts adipogenesis. Here, we identify HDAC4 as a regulator of Pax7-dependent muscle regeneration. In HDAC4-deficient SCs, the expression of Pax7 and its target genes is reduced. We identify HDAC4-regulated Lix1 as a Pax7 target gene required for SC ...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2014
Ping Mu Vishwa Deepak Liheng Kang Qing Jiang Rong Liu Lingyi Meng Zhongli Zhang Xianlu Zeng Wenguang Liu

Histone deacetylases (HDACs) are a group of enzymes that deacetylate ε-N-acetyl lysine residues of histone and non-histone proteins and play an important role in gene regulation. HDAC4, a class-IIa HDAC, has been reported to shuttle between nucleus and cytoplasm in response to various cellular stimuli. The nucleo-cytoplasmic shuttling of HDAC4 is critical, and an anomalous nuclear localization ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Timothy A Bolger Tso-Pang Yao

Histone deacetylase 4 (HDAC4) undergoes signal-dependent shuttling between the cytoplasm and nucleus, which is regulated in part by calcium/calmodulin-dependent kinase (CaMK)-mediated phosphorylation. Here, we report that HDAC4 intracellular trafficking is important in regulating neuronal cell death. HDAC4 is normally localized to the cytoplasm in brain tissue and cultured cerebellar granule ne...

2016
Yu Tina Zhao Hao Wang Shouyan Zhang Jianfeng Du Shougang Zhuang Ting C. Zhao

Irisin is a recently identified myokine which brings increases in energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissues. However, its effects in the heart remains unknown. This study sought to determine the effects of irisin on hypoxia/reoxygenation injury and its relationship with HDAC4. Wild type and stable HDAC4-overexpression ...

Journal: :Molecular and cellular biology 2005
Laura Micheli Luca Leonardi Filippo Conti Pasquale Buanne Nadia Canu Maurizia Caruso Felice Tirone

Histone deacetylase 4 (HDAC4) negatively regulates skeletal myogenesis by associating with the myocyte enhancer factor 2 (MEF2) transcription factors. Our data indicate that the gene PC4 (interferon-related developmental regulator 1 [IFRD1], Tis7), which we have previously shown to be required for myoblast differentiation, is both induced by MyoD and potentiates the transcriptional activity of ...

Journal: :Molecular and cellular biology 1999
A H Wang N R Bertos M Vezmar N Pelletier M Crosato H H Heng J Th'ng J Han X J Yang

Histone acetylation plays an important role in regulating chromatin structure and thus gene expression. Here we describe the functional characterization of HDAC4, a human histone deacetylase whose C-terminal part displays significant sequence similarity to the deacetylase domain of yeast HDA1. HDAC4 is expressed in various adult human tissues, and its gene is located at chromosome band 2q37. HD...

2015
Fei Yue Wenjiao Li Jing Zou Qi Chen Guibin Xu Hai Huang Zhen Xu Sheng Zhang Paola Gallinari Fen Wang Wallace L. McKeehan Leyuan Liu

Autophagy controls and executes the turnover of abnormally aggregated proteins. MAP1S interacts with the autophagy marker LC3 and positively regulates autophagy flux. HDAC4 associates with the aggregation-prone mutant huntingtin protein (mHTT) that causes Huntington's disease, and colocalizes with it in cytosolic inclusions. It was suggested HDAC4 interacts with MAP1S in a yeast two-hybrid scre...

2011
Johannes Backs Barbara C. Worst Lorenz H. Lehmann David M. Patrick Zegeye Jebessa Michael M. Kreusser Qiang Sun Lan Chen Claudia Heft Hugo A. Katus Eric N. Olson

Histone deacetylase 4 (HDAC4) regulates numerous gene expression programs through its signal-dependent repression of myocyte enhancer factor 2 (MEF2) and serum response factor (SRF) transcription factors. In cardiomyocytes, calcium/calmodulin-dependent protein kinase II (CaMKII) signaling promotes hypertrophy and pathological remodeling, at least in part by phosphorylating HDAC4, with consequen...

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