نتایج جستجو برای: ژن bmp15
تعداد نتایج: 16034 فیلتر نتایج به سال:
Partial neutralization of bone morphogenetic protein 15 (BMP15) bioactivity by immunization is known to increase ovulation rate in sheep. However, it remains uncertain whether BMP15 vaccination would be a suitable procedure for increasing lambing rate. The aim of this study was to compare the efficacy of a BMP15 vaccination treatment on lamb production to that of commercially-available androste...
Bone Morphogenetic Protein 15 (BMP15) is a TGFβ-like oocyte-derived growth factor involved in ovarian folliculogenesis as a critical regulator of many granulosa cell processes. Alterations of the BMP15 gene have been found associated with different ovarian phenotypic effects depending on the species, from sterility to increased prolificacy in sheep, slight subfertility in mouse or associated wi...
BACKGROUND A large number of studies have contributed to understanding the general mechanisms driving ovarian folliculogenesis in humans and show a complex endocrine dialog between the central nervous system, the pituitary and the ovary, integrated by various intraovarian paracrine messages. The role of intraovarian paracrine regulation has acquired more relevance in the recent years owing to t...
Bone morphogenetic proteins (BMPs) and the growth factors (GDFs) play an important role in ovarian folliculogenesis and essential regulator of processes of numerous granulosa cells. BMP15 gene variations linked to various ovarian phenotypic consequences subject to the species, from infertility to improved prolificacy in sheep, primary ovarian insufficiency in women or associated with minor subf...
چکیده هدف از انجام این تحقیق شناسایی چندشکلی های تک نوکلئوتیدی موجود در ژن های فاکتور رشد و تمایز9 (gdf9) و پروتئین مورفوژنتیک استخوانی 15 (bmp15) در گوسفند نژاد ایران بلک وتاثیر آنها بر میزان بره زایی درگوسفند ایران بلک بود.نمونه های خون از140 میش ایران بلک جمع آوری شد. استخراج dna به روش استخراج نمکی از خون کامل انجام شد.دراین تحقیق از روش pcr-rflp ارائه شده توسط هانراهان و همکاران برای شنا...
The present study has evaluated the association of growth differentiation factor9 (GDF9) and bone morphogenetic protein15 (BMP15) mRNA expression in cumulus-oocyte complexes (COCs) of buffalo ovary during in vitro maturation (IVM). GDF9 and BMP15 are expressed specifically in mammalian oocytes and also participate in cumulus-oocyte crosstalk. Quantitative real-time polymerase chain reaction (qR...
هدف از انجام تحقیق حاضر، بررسی چندشکلی ژن bmp15 که در کنترل شرح و بسط فولیکول در تخمدان، نرخ تخمکگذاری، و باروری نقش حیاتی دارد، است. نمونه های خون از 91 بز نجدی مربوط به سه موقعیت جغرافیایی شمال غربی، جنوب شرقی، و مرکز استان خوزستان به طور تصادفی انتخاب شدند. بعد از استخراج dna، تکثیر قطعۀ 235 جفت بازی از اگزون دو ژن bmp15 با استفاده از یک جفت آغازگر اختصاصی انجام شد و قطعات مورد نظر توالییا...
Bone morphogenetic protein 15 (BMP15) is a member of the transforming growth factor beta superfamily, is specifically expressed in oocytes and is essential for sheep prolificacy. Reported mutations in this gene cause increased ovulation rate and infertility in a dosage-sensitive manner. In this work, a new naturally occurring mutation in the BMP15 gene from the ovine Rasa Aragonesa breed is des...
BACKGROUND AND OBJECTIVE Mutations in bone morphogenic protein 15 (BMP15) and growth/differentiation factor 9 (GDF9) lead to altered fertility in animal models. In the human, a heterozygous point mutation of BMP15 has been associated with premature ovarian failure (POF). SUBJECT AND METHODS We have directly sequenced both genes in a cohort of 203 POF patients presenting with primary or second...
In the ovary, connexin-coupled gap junctions in granulosa cells play crucial roles in follicular and oocyte development as well as in corpus luteum formation. Our previous work has shown that theca cell-derived bone morphogenetic protein (BMP)4 and BMP7 decrease gap junction intercellular communication (GJIC) activity via the down-regulation of connexin43 (Cx43) expression in immortalized human...
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