purpose: to report a case of pseudoexfoliation syndrome in young keratoconus patient following penetrating keratoplasty. case report: a 37 year old man who underwent penetrating keratoplasty 13 years ago in his left eye due to keratoconus developed pseudoexfoliation (pex) syndrome in the operated eye. apart from pex material deposition on the crystalline lens ophthalmic exam was within normal l...

purpose : the objective of this study was to investigate the total antioxidant status (tas) and dna damage markers of serum and aqueous humor in patients with pseudoexfoliation (pex) syndrome. methods : twenty-seven cataract patients with pex and twenty-seven without pex syndrome were included in the study and groups were matched for age and gender. patients had no elevated intraocular pressure...

A unique characteristic of neural stem cells is their capacity to track glioma cells that have migrated away from the main tumor mass into the normal brain parenchyma. PEX, a naturally occurring fragment of human metalloproteinase-2, acts as an inhibitor of glioma and endothelial cell proliferation, migration, and angiogenesis. In the present study, we evaluated the antitumor activity of PEX-pr...

Pseudoexfoliation syndrome (PEX Sy) is a common age–related disorder of the extracellular matrix that is frequently associated with severe secondary chronic open-angle glaucoma and cataract. Pseudoexfoliation glaucoma (PEX gl) is one of the most common causes of optic disc damage, low visual accuracy, damage of visual field and blidness. Deposits of white material on the anterior lens surface a...

OBJECTIVES To evaluate the anterior segment biometric features and corneal endothelial changes in eyes with pseudoexfoliation (PEX) syndrome and senile cataract. MATERIALS AND METHODS The central corneal thickness, anterior chamber depth (ACD), pupil diameter, lens thickness, endothelial cell density (ECD), and percentages of polymegathism and pleomorphism of 52 subjects with PEX and cataract...

A systematic literature review was performed evaluating articles examining the effects of pseudoexfoliation syndrome (PEX) and glaucoma (PEXG) on the cornea with a focus on the corneal endothelium. We searched for articles relevant to pseudoexfoliation syndrome, pseudoexfoliation glaucoma and corneal endothelial cell counts using Pubmed, Google Scholar Database, Web of Science and Cochrane Libr...

Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in malignancy. The structure of MT1-MMP includes the hemopexin domain (PEX) that is distinct from and additional to the catalytic domain. Current MMP inhibitors target the conserved active site in the catalytic domain and, as a result, repress the proteolytic activity of multiple MMPs instead of MT1-MMP alone. In our ...