Background—Silent information regulator 1 (Sirt1), a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R). Methods and Results—Protein and mRNA expression of Sirt1 is significantly reduced by I/R. Cardiac-specific Sirt1 Ϫ/Ϫ mice exhibited a significant increase (44Ϯ5%...

Sirtuin 1 (Sirt1) is a gene with diverse and complex roles in metabolic regulation, tumorigenesis and longevity, the latter being highly debated. Sirt1 is one of seven sirtuins that are NAD+ dependent and that, depending on the family member, modify histone and non-histone proteins by deacetylation and/or mono-ADP-ribosylation. Excellent reviews detail the long list of Sirt1 targets for deacety...

Aim. Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators. However, the relationship between SIRT1 and autophagy in GC has not been defined. Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relationship in GC patients. Methods. Transmission electron microscopy (TEM) was performed to examine the...

Introduction: Diabetic nephropathy (DN) is one of the major microvascular complications diabetes mellitus. Patients with diabetic are at a higher risk morbidity and mortality than those without nephropathy. In this case, early diagnosis prevention DM crucial. SIRT1, which among seven members sirtuins, recognized as an important element in pathogenesis type 2 diabetes, therefore it has several a...

Activation of sirtuin 1 (Sirt1) attenuates unilateral ureteral obstruction (UUO)-induced inflammation and fibrosis, suggesting that Sirt1 may prevent tubulointerstitial fibrosis. In this study, we explored changes in the expression of Sirt1 in the kidneys of UUO-treated rats and evaluated the effects of Sirt1 activation or inhibition on renal pathology and mediators of UUO pathogenesis, especia...

Abstract Objectives Periodontitis, a dental disease that causes inflammation of gums is triggered by bacterial infection. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) has been reported to participate in inflammatory diseases. In the present study, we investigated effects lncRNA MALAT1 on periodontal ligament cells (PDLCs) with lipopolysaccharide (LP...

background: little in known regarding the clinical relevance of sirt1 in multiple sclerosis (ms).   here, we aimed to evaluate mrna expression, protein level and enzyme activity of sirt1 in peripheral blood mononuclear cells (pbmcs) isolated from relapsing –remitting ms patients (rrms) and healthy controls. materials and methods: twenty patients with rr-ms and twenty two age- and sex-matched he...