نتایج جستجو برای: چارچوب gof
تعداد نتایج: 18532 فیلتر نتایج به سال:
In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process-from selection of candidate vaccine viruses (CVVs...
BACKGROUND Patients with PCSK9 gene gain of function (GOF) mutations have a rare form of autosomal dominant hypercholesterolemia. However, data examining their clinical characteristics and geographic distribution are lacking. Furthermore, no randomized treatment study in this population has been reported. METHODS AND RESULTS We compiled clinical characteristics of PCSK9 GOF mutation carriers ...
Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itself in accelerated tumor onset, increased metastasis, increased drug resistance and shortened survival in patients and mice. A known prerequisite fo...
The tumour suppressor p53 is frequently mutated in tumours. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 can accumulate to high levels in tumours, which promotes mutp53 GOF in tumorigenesis. The mechanism of mutp53 accumulation is poorly understood. Here we find that MDM2 isoforms promote mutp53 accumulation in tumo...
The optimum surface-fitting method for binary images is extended in order to treat gray images, and a new method to extract edges in three-dimensional gray images is proposed. If voxels that have similar values to the voxel of interest (VOI) are distributed like a two-dimensional curved surface, it is thought that there would be a curved surface at the VOI. To apply the fitting method to gray i...
Résumé. Dans cet article, nous introduisons une nouvelle mesure pour qualifier “l’outlier-ness“ de chaque groupe/cluster. Cette mesure, nommée GOF, est intégrée et estimée dans un processus d’apprentissage non supervisé en utilisant les cartes topologiques. Ceci permet d’apprendre la structure des données tout en fournissant un nouveau score (GOF). Ce paramètre est basé sur la densité et quanti...
This paper discusses a recent development in partial least squares (PLS) path modeling, namely goodness-of-fit indices. In order to illustrate the behavior of the goodness-of-fit index (GoF) and the relative goodness-of-fit index (GoFrel), we estimate PLS path models with simulated data, and contrast their values with fit indices commonly used in covariance-based structural equation modeling. T...
The Department of Health and Human Services Framework for Guiding Funding Decisions about Proposed Research Involving Enhanced Potential Pandemic Pathogens (PPPs) contains a series of principles for governing the funding and conduct of gain-of-function (GOF) research resulting in the creation of PPPs. In this article, I address one of these principles, governing the replacement of GOF research ...
Moving objects of interest (MOOIs) in surveillance videos are detected and encapsulated by bounding boxes. Since moving objects are defined by temporal activities through the consecutive video frames, it is necessary to examine a group of frames (GoF) to detect the moving objects. To do that, the traces of moving objects in the GoF are quantified by forming a spatiotemporal gradient map (STGM) ...
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