نتایج جستجو برای: چارچوب gof

تعداد نتایج: 18532  

2014
S. Schultz-Cherry R. J. Webby R. G. Webster A. Kelso I. G. Barr J. W. McCauley R. S. Daniels D. Wang Y. Shu E. Nobusawa S. Itamura M. Tashiro Y. Harada S. Watanabe T. Odagiri Z. Ye G. Grohmann R. Harvey O. Engelhardt D. Smith K. Hamilton F. Claes G. Dauphin

In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process-from selection of candidate vaccine viruses (CVVs...

2015
Paul N. Hopkins Joep Defesche Sigrid W. Fouchier Eric Bruckert Gérald Luc Bertrand Cariou Barbara Sjouke Trond P. Leren Mariko Harada-Shiba Hiroshi Mabuchi Jean-Pierre Rabès Alain Carrié Charles van Heyningen Valérie Carreau Michel Farnier Yee P. Teoh Mafalda Bourbon Masa-aki Kawashiri Atsushi Nohara Handrean Soran A. David Marais Hayato Tada Marianne Abifadel Catherine Boileau Bernard Chanu Shoji Katsuda Ichiro Kishimoto Gilles Lambert Hisashi Makino Yoshihiro Miyamoto Matthieu Pichelin Kunimasa Yagi Masakazu Yamagishi Yassine Zair Scott Mellis George D. Yancopoulos Neil Stahl Johanna Mendoza Yunling Du Sara Hamon Michel Krempf Gary D. Swergold

BACKGROUND Patients with PCSK9 gene gain of function (GOF) mutations have a rare form of autosomal dominant hypercholesterolemia. However, data examining their clinical characteristics and geographic distribution are lacking. Furthermore, no randomized treatment study in this population has been reported. METHODS AND RESULTS We compiled clinical characteristics of PCSK9 GOF mutation carriers ...

2017
Evguenia M Alexandrova Safia A Mirza Sulan Xu Ramona Schulz-Heddergott Natalia D Marchenko Ute M Moll

Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their tumor-suppressor activity, but often acquire oncogenic gain-of-functions (GOFs). GOF manifests itself in accelerated tumor onset, increased metastasis, increased drug resistance and shortened survival in patients and mice. A known prerequisite fo...

2013
Tongsen Zheng Jiabei Wang Yuhan Zhao Cen Zhang Meihua Lin Xiaowen Wang Haiyang Yu Lianxin Liu Zhaohui Feng Wenwei Hu

The tumour suppressor p53 is frequently mutated in tumours. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 can accumulate to high levels in tumours, which promotes mutp53 GOF in tumorigenesis. The mechanism of mutp53 accumulation is poorly understood. Here we find that MDM2 isoforms promote mutp53 accumulation in tumo...

2005
Yasushi Hirano Sidney Fels

The optimum surface-fitting method for binary images is extended in order to treat gray images, and a new method to extract edges in three-dimensional gray images is proposed. If voxels that have similar values to the voxel of interest (VOI) are distributed like a two-dimensional curved surface, it is thought that there would be a curved surface at the VOI. To apply the fitting method to gray i...

2014
Amine Chaibi Mustapha Lebbah Hanene Azzag

Résumé. Dans cet article, nous introduisons une nouvelle mesure pour qualifier “l’outlier-ness“ de chaque groupe/cluster. Cette mesure, nommée GOF, est intégrée et estimée dans un processus d’apprentissage non supervisé en utilisant les cartes topologiques. Ceci permet d’apprendre la structure des données tout en fournissant un nouveau score (GOF). Ce paramètre est basé sur la densité et quanti...

2017
Jörg Henseler Marko Sarstedt

This paper discusses a recent development in partial least squares (PLS) path modeling, namely goodness-of-fit indices. In order to illustrate the behavior of the goodness-of-fit index (GoF) and the relative goodness-of-fit index (GoFrel), we estimate PLS path models with simulated data, and contrast their values with fit indices commonly used in covariance-based structural equation modeling. T...

2018
Nicholas Greig Evans

The Department of Health and Human Services Framework for Guiding Funding Decisions about Proposed Research Involving Enhanced Potential Pandemic Pathogens (PPPs) contains a series of principles for governing the funding and conduct of gain-of-function (GOF) research resulting in the creation of PPPs. In this article, I address one of these principles, governing the replacement of GOF research ...

2014
Anh Vu Le Seung-Won Jung Chee Sun Won

Moving objects of interest (MOOIs) in surveillance videos are detected and encapsulated by bounding boxes. Since moving objects are defined by temporal activities through the consecutive video frames, it is necessary to examine a group of frames (GoF) to detect the moving objects. To do that, the traces of moving objects in the GoF are quantified by forming a spatiotemporal gradient map (STGM) ...

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