BACKGROUND The N-terminal fragments of A- and B-type natriuretic peptides (NT-proANP and NT-proBNP) are powerful markers of cardiac function. The current assays require refinement with regard to standardization with native calibrators and the ability to detect the actual circulating forms. METHODS The following peptides were prepared with recombinant methods: NT-proANP, NT-proBNP, proBNP1-108...

Background: B-type natriuretic peptide (BNP) and the inactive amino-terminal pro-B-type natriuretic peptide (NTproBNP) have a prognostic value in heart failure and in myocardial infarction. There has been some evidence that BNP and NT-proBNP can be used in the diagnosis of myocardial ischaemia by improving the sensitivity of exercise-stress testing. Objective: To observe the relationship betwee...

1024x768 normal 0 false false false en-us x-none fa background : heart failure is a common health problem with poor prognosis. the gold standard for diagnosis is echocardiography but it is not always reachable, especially in emergency conditions. nt-pro-brain natriuretic peptide (nt-probnp) is a novel indicator for the diagnosis of heart failure and is being used in routine tests in emergency r...

AIM To investigate the association between plasma concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and formation of esophageal varices. METHODS Thirty-five patients with alcoholic cirrhosis were divided into three groups according to the Child-Pugh classification: grade A (n=11, 32%), B (n=12, 34%), and C (n=12, 34%). System hemodynamic parameters were measured using sp...

BACKGROUND B-type natriuretic peptide (BNP) and the inactive amino-terminal pro-B-type natriuretic peptide (NTproBNP) have a prognostic value in heart failure and in myocardial infarction. There has been some evidence that BNP and NT-proBNP can be used in the diagnosis of myocardial ischaemia by improving the sensitivity of exercise- stress testing. OBJECTIVE To observe the relationship betwe...

I. Overview of Heart Failure. . . . . . . . . . . . . . . . . . . . . . .e99 A. Context of Biochemical Marker Testing in Heart Failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e99 B. Background and Definition of Terms . . . . . . . . . .e100 C. B-type Natriuretic Peptide (BNP) and AminoTerminal proB-Type Natriuretic Peptide (NT-proBNP) Metabolism and Measurement . . . .e100 I...

B-type natriuretic peptide (BNP) is a 32 amino acid cardiacsynthesized hormone that reduces blood pressure and increases sodium excretion (1 ). Following proteolytic cleavage of proBNP, a 108-amino acid precursor, an Nterminal fragment (NT-proBNP) and BNP are released (2 ). Increased concentrations of BNP and NT-proBNP can be used clinically to monitor heart failure, but a lack of alignment bet...

BACKGROUND Exercise is associated with changes in circulating B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP). However, the biological relevance of this phenomenon is poorly examined. We sought to assess determinants of absolute (Δ) and relative (Δ%) exercise-induced changes in BNP and NT-proBNP. METHODS BNP (n = 418) and NT-proBNP (n = 478) at rest and peak exercise were m...