This paper describes the design and implementation of a current-mode phase-locked loop (PLL) using static and dynamic (log-domain) translinear circuits. The loop is fully tuneable, with independent control of center frequency and loop bandwidth. The loop employs a recently proposed current-mode “log-domain” oscillator in a classical PLL topology to obtain these features. The PLL has been fabric...

One hundred and fifty patients of epileptic psychosis, registered over a period of five years in neuropsychiatry clinics at NIMHANS were studied. Patients with organic causes which may produce both epilepsy and psychosis were excluded. The epileptic psychosis ratio to epilepsy was 1:23 and the epileptic psychosis ratio to psychosis was 1:75. The mean age at the onset of epilepsy was 19.4 years,...

The place of Neandertals in modern human emergence has been a subject of debate since the first recognized Neandertal skeleton was discovered in 1856. This paper presents an overview of morphological, archaeological, and genetic evidence commonly used in discussions of Neandertals and their evolutionary significance. A brief historical sketch of the argument provides insight into the changing v...

ThehumanpregnaneX receptor (hPXR) is a xenobiotic-sensing nuclear receptor that transcriptionally regulates drug metabolism–related genes. The aim of the present study was to elucidate the mechanism by which hPXR is regulated through threonine-408. A phosphomimetic mutationat threonine-408 (T408D) reduced the transcriptional activity of hPXR and its protein stability in HepG2 and SW480 cells in...