PURPOSE The cyclolignan picropodophyllin (PPP) efficiently blocks the activity of insulin-like growth factor-1 receptor (IGF-1R) and inhibits growth of uveal melanoma cells in vitro and in vivo. In this study, we aimed to investigate the efficiency of orally administered PPP on growth of uveal melanoma xenografts. Further, we focused on the effect of PPP on vascular endothelial growth factor (V...

Pustulosis palmaris et plantaris (PPP) is a chronic relapsing skin disease characterized by sterile intraepidermal pustules and, usually, by scaly erythematous skin on the palm, soles, or both. To determine the primary pathogenic factors involved in the onset of PPP, we analyzed the implications of heat shock proteins (HSPs), which are highly conserved immunogenic proteins, chronic microbial in...

BACKGROUND The mortality rate of patients with hemodynamic instability due to severe pelvic fracture is reported to be 40-60% despite a multidisciplinary treatment approach. Angioembolization and external fixation of the pelvis are the main procedures used to control bleeding in these patients. Several studies have shown that preperitoneal pelvic packing (PPP) is effective for hemorrhage contro...

"Pustulosis palmaris et plantaris", or palmoplantar pustulosis (PPP), is a chronic pustular dermatitis characterized by intraepidermal palmoplantar pustules. Although early stage vesicles (preceding the pustular phase) formed in the acrosyringium contain the antimicrobial peptides cathelicidin (hCAP-18/LL-37) and dermcidin, the details of hCAP-18/LL-37 expression in such vesicles remain unclear...

Palmoplantar pustulosis (PPP) is considered to be a variant of psoriasis, although recently it has been shown to be genetically different from psoriasis vulgaris (1). The majority of patients with PPP are women and smokers. The final target for inflammation in this condition is the palmoplantar sweat duct (2, 3), but the mechanisms underlying the inflammation are poorly characterized. PPP patie...

BACKGROUND/AIM Isolated stenosis of the lacrimal punctum is a frequent cause of epiphora. Treatment relies on surgical opening or dilatation with bi- or monocanalicular prosthesis. Recently, silicone perforated punctum plugs (PPP) were proposed. The drawback with these silicone PPP was that secretions accumulate in the central orifice blocking the spontaneous flow of tears. A modification of th...

Currently, the precise point positioning (PPP) technique is a well-established GNSS processing method for postprocessing applications, while real-time PPP is still a field of ongoing research. Meanwhile a new RTCM (Radio Technical Commission for Maritime Services) standard for exchanging PPP corrections has been released. This so-called state space representation (SSR) contains orbit and clock ...

patients and methods we conducted an observational prospective study in adults proposed to various types of surgery using the brief pain inventory short form preoperatively (t0), one day after surgery, and three months later (t3). if the patient had pain at t3 and other causes of pain were excluded, they were considered to have ppp, and the mcgill pain questionnaire short form was applied. qol ...

the mechanism of public-private partnership (ppp) has been used in different countries. many countries have enacted special laws to regulate ppps. in iran, ppp as such has been briefly mentioned in the fifth five year development act and more details of ppps were provided in the yearly budget acts of 1391 and 1392 (2012 and 2013). in the budget act of 1393 (2014) the detailed provisions regardi...