Nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the transcription factors involved in providing endogenous antioxidants. Black seed oil (BSO), suspected have antioxidant effects that can be used to modulate the expression and levels of Nrf2. The study aims to determine the effect of BSO as adjuvant therapy on levels of Nrf2 to the patients with metabolic syndrome risk. The re...

objective(s): this study aims to determine the effects of ozone therapy on restoring impaired nrf2 activation to ameliorate chronic tubulointerstitial injury in rats with adenine-induced ckd. materials and methods: sprague–dawley rats were fed with 0.75% adenine-containing diet to induce ckd and chronic tubulointerstitial injury. ozone therapy was administered by rectal insufflation. after 4 we...

Nrf2 (Nfe2l2) governs cellular defenses against oxidative and electrophilic stresses and protects against chemical carcinogenesis. However, many cancers have been found to accumulate NRF2 protein, raising questions of precisely how Nrf2 contributes to carcinogenesis. In this report, we explored such questions in an established urethane-induced multistep model of lung carcinogenesis. Consistent ...

Pulmonary macrophages are one of the sources of various antioxidant and detoxification enzymes for which NF-E2-related factor 2 (Nrf2) is a key transcriptional factor. Although Nrf2 deficiency reportedly induces severe emphysema in smoking mice, no reports have studied Nrf2 regulation in chronic obstructive pulmonary disease (COPD). In this study, Nrf2 activation in response to cigarette smoke ...

The transcription factor Nrf2 regulates cellular redox homeostasis. Under basal conditions, Keap1 recruits Nrf2 into the Cul3-containing E3 ubiquitin ligase complex for ubiquitin conjugation and subsequent proteasomal degradation. Oxidative stress triggers activation of Nrf2 through inhibition of E3 ubiquitin ligase activity, resulting in increased levels of Nrf2 and transcriptional activation ...

Targeting Nrf2 signaling appears to be an attractive approach for the treatment of maladaptive cardiac remodeling and dysfunction; however, pharmacological modulation of the Nrf2 pathway in the cardiovascular system remains to be established. Herein, we report that a novel synthetic triterpenoid derivative, dihydro-CDDO-trifluoroethyl amide (dh404), activates Nrf2 and suppresses oxidative stres...

Background: Elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...

A basic leucine zipper transcription factor, NF-E2-related factor 2 (Nrf2), plays a critical role in the cellular defense mechanism by mediating a coordinate up-regulation of antioxidant responsive element-driven detoxification and antioxidant genes. Here, we report that targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia due to increased sequestration of damaged er...

زمینه و هدف: فعالیت‌های ورزشی چاقی، رگ‌زایی در بافت چربی را تغییر می‌دهند نتیجه تغییرات زیادی فرایندهای متابولیکی ایجاد می‌کنند. هدف از این پژوهش مقایسة تأثیر هشت هفته تمرین مقاومتی تناوبی هوازی با شدت بالا بر بیان miRNAهای مرتبط ضدرگ‌زایی موش‌های صحرایی تغذیه‌شده رژیم غذایی پرچرب بود.مواد روش‌ها: بنیادی تجربی حاضر، 60 سر موش نر ویستار شش‌هفته‌ای ( g35/11 ± 40/192 = میانگین وزن بدن) انستیتو پاس...