The biosynthesis of eukaryotic lipid-linked oligosaccharides (LLOs) that act as donor substrates in eukaryotic protein N-glycosylation starts on the cytoplasmic side of the endoplasmic reticulum and includes the sequential addition of five mannose units to dolichol-pyrophosphate-GlcNAc2. These reactions are catalyzed by the Alg1, Alg2 and Alg11 gene products and yield Dol-PP-GlcNAc2Man5, an LLO...

Lithium-rich layered oxides (LLOs) with high energy density and low cost are regarded as promising candidates for the next-generation cathode materials lithium-ion batteries (LIBs). However, there still some drawbacks of LLOs such oxygen instability irreversible structure reconstruction, which seriously limit their electrochemical performance practical applications. Herein, high-valence Ta dopi...

BACKGROUND Ultrasound-guided paracentesis is commonly performed in the emergency department (ED) setting. Injury to the inferior epigastric artery (IEA) is an uncommon but potentially life-threatening complication of paracentesis. Use of anatomic landmarks has been recommended to avoid this structure. If feasible, sonographic localization of the IEA before ultrasound-guided paracentesis may pro...

The neuronal ceroid lipofuscinoses (NCLs, also known collectively as Batten disease) are a group of lysosomal storage disorders characterized by the accumulation of autofluorescent storage material in the brain and other tissues. A number of genes underlying various forms of NCL have been cloned, but the basis for the neurodegeneration in any of these is unknown. High levels of dolichol pyropho...

BACKGROUND Edoxaban is an oral, direct, factor Xa inhibitor approved in Japan for thromboembolic prophylaxis after lower-limb orthopedic surgery (LLOS), but contraindicated in patients with severe renal impairment (SRI; creatinine clearance [CLCR] ≥15 to <30 mL/min). METHODS This open-label study compared the safety of edoxaban 15 mg once daily in Japanese patients with SRI to that of edoxaba...

How does growth heterogeneity affect countries’ incentives to enter an international environmental agreement (IEA)? We address this issue in a twocountry model of endogenous growth. Two countries differ in their initial capital stocks, emulating a more developed country and a less developed one. Each country’s setup takes after that of Stokey (1998) but pollution is transboundary. Absent an IEA...