Bacterial infections can be aggravated by antibiotic treatment that induces SOS response and vesiculation. This leads to a hypothesis concerning association of SOS with vesiculation. To test it, we conducted multiple analyses of outer membrane vesicles (OMVs) produced from the Pseudomonas aeruginosa wild type in which SOS is induced by ciprofloxacin and from the LexA noncleavable (lexAN) strain...

Understanding System of Systems (SoS) requires novel ways to apply systems engineering processes. Acknowledged SoS have recognized objectives, a designated manager and resources for the SoS. The goal of this research is to develop a proof of concept tool suite for Acknowledged SoS systems simulation. This suite is named flexible, intelligent and learning architectures for System of Systems (FIL...

System-of-systems (SoS) architectures based on common software platforms have been commercially successful. Common platforms are a goal of several DoD initiatives (US Army Common Operating Environment, US Navy Open Architecture, multi-service Future Avionics Capability Environment), but progress on creating and adopting such platforms has been slow. We conducted a study to understand the techni...

In contrast to a transition system specification in process algebra, a structural operational semantics (SOS) of a programming language usually involves auxiliary entities: stores, environments, etc. When specifying SOS rules, particular auxiliary entities often need to be propagated unchanged between premises and conclusions. The standard technique is to make such propagation explicit, using v...

Sucrose octasulfate (SOS) is believed to stimulate fibroblast growth factor (FGF) signaling by binding and stabilizing FGFs. In this report, we show that SOS induces FGF-dependent dimerization of FGF receptors (FGFRs). The crystal structure of the dimeric FGF2-FGFR1-SOS complex at 2.6-A resolution reveals a symmetric assemblage of two 1:1:1 FGF2-FGFR1-SOS ternary complexes. Within each ternary ...

One of the key issues facing architects of systems of systems (SOS) is the emergent nature of the context of the SOS. In the spirit of Herbert Simon, context here means all the stakeholders, objects, processes and other external effects that create the environment for goal attainment of a system. As SOS are systems, they too have contexts. Understanding the relationship between the contexts of ...

INTRODUCTION............................................................ 61 PROCESSING OF DAMAGED DNA ............................................................ 61 SOS REGULATORY NETWORK ............................................................. 61 Present Model for SOS Regulation ............................................................ 62 SOS Responses ...................................

The concept of veno-occlusive disease (VOD), along with our understanding of it, has historically been and remains an evolving phenomenon. This review presents a broad view of VOD, also known as sinusoidal obstruction syndrome (SOS), including (1) traditional hematopoietic stem cell transplant-associated VOD/SOS, (2) late-onset VOD/SOS, (3) pulmonary VOD, and (4) VOD/SOS associated with chemoth...

Insulin and epidermal growth factor (EGF) stimulate a rapid but transient increase in the amount of GTP bound to Ras that returns to the basal GDP-bound state within 10-30 min. Although insulin stimulation resulted in a dissociation of the Grb2.SOS complex, EGF did not affect the Grb2.SOS complex but instead induced dissociation of Grb2-SOS from tyrosine-phosphorylated Shc. The dissociation of ...