نتایج جستجو برای: پاروویروس 19b
تعداد نتایج: 471 فیلتر نتایج به سال:
This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardia...
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma, which shows high aggressiveness and lacks biomarkers. RhoB acts as a tumor suppressor that inhibits the progression of ccRCC. In the present study, we examined the effects of oncogenic microRNAs, miR-19a and miR-19b, on RhoB expression in ccRCC cells. The results showed that both miR-19a and miR-19b coul...
In this study, three-day old mature biofilms of Escherichia coli were exposed once to either a temperate Shiga-toxin encoding phage (H-19B) or an obligatory lytic phage (T7), after which further dynamics in the biofilm were monitored. As such, it was found that a single dose of H-19B could rapidly lead to a near complete lysogenization of the biofilm, with a subsequent continuous release of inf...
چکید ه سابقه و هدف پاروویروس B19 موجب بروز طیفی از تظاهرات بالینی از جمله اریتم عفونی، هیدروپس فتالیس، آرتروپاتی و بحران آپلاستیک گذرا می‌شود. ویروس بسیار بیماری‌زا است و از طریق تنفس، خون و فرآورده‌های آن انتقال مییابد. هدف این مطالعه، جستجوی ژنومی پاروویروس انسانی B19 در افراد مبتلا به اختلالات خونی بود. مواد و روش‌ها در یک مطالعه توصیفی، عفونت به پاروویروس B19 در بین بیماران مبتلا...
� چکید ه سابقه و هدف پاروویروس B19 انسانی، ویروسی بسیار کوچک با DNA تک رشته‌ای، بدون پوشش و عضو خانواده پاروویریده می‌باشد. پاروویروس B19 انسانی موجب بروز تعدادی از بیماری‌های بالینی شامل اریتمای عفونی(بیماری پنجم)، هیدروپس فتالیس، بحران آپلاستیک گذرا، آرتروپاتی و کم خونی مادرزادی می‌شود. انتقال ویروس از طریق تنفس، انتقال خون و فرآورده‌های خونی است. DNA ی B19 از طریق روش‌های حساس PCR قابل...
Protein tyrosine phosphatase receptor type G (PTPRG) is an important tumor suppressor gene in multiple human cancers. In this study, we found that PTPRG protein levels were downregulated in breast cancer tissues while the mRNA levels varied irregularly, implying a post-transcriptional mechanism was involved. Because microRNAs are powerful post-transcriptional regulators of gene expression, we u...
Transforming growth factor-β1 (TGF-β1) plays an important role on fibrogenesis in heart disease. MicroRNAs have exhibited as crucial regulators of cardiac homeostasis and remodeling in various heart diseases. MiR-19a-3p/19b-3p expresses with low levels in the plasma of heart failure patients. The purpose of our study is to determine the role of MiR-19a-3p/19b-3p in regulating autophagy-mediated...
The biological effects of microRNAs (miRNAs) and TNF-α in atherosclerosis have been widely studied. The circulating miR-17-92 cluster has been recently shown to be significantly downregulated in patients with injured vascular endothelium. However, it remains unclear whether the miR-17-92 cluster plays a significant role in vascular endothelial repair. The aim of this study was to investigate th...
The synergism between c-MYC and miR-17-19b, a truncated version of the miR-17-92 cluster, is well-documented during tumor initiation. However, little is known about miR-17-19b function in established cancers. Here we investigate the role of miR-17-19b in c-MYC-driven lymphomas by integrating SILAC-based quantitative proteomics, transcriptomics and 3' untranslated region (UTR) analysis upon miR-...
Analysis of the DNA sequence of a 17 kb region of the coli lambdoid phage H-19B genome located the genes encoding shiga-like toxin I (Stx-I) downstream of the gene encoding the analogue of the phage lambda Q transcription activator with its site of action, qut at the associated pR' late promoter, and upstream of the analogues of lambda genes encoding lysis functions. Functional studies, includi...
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