Herpes simplex virus type-1 (HSV-1) causes a variety of diseases in human. This virus is a neurotropic pathogen of human that establishes latent infection in the sensory ganglia innervating the site of primary infection. A number of genes including ICP34.5 control HSV-1 pathogenicity and ICP34.5 has been identified as HSV-1 virulence gene. Open reading frame P (ORF P) is also a HSV-1 gene that ...

The open-shell iron pentacarbonyl cation [Fe(CO)5].+ was isolated by deelectronation, i.e., the single-electron oxidation of parent neutral Fe(CO)5 using [phenazineF].+ as [Al(ORF)4]− and [F-{Al(ORF)3}2]− salt (RF=C(CF3)3; phenazineF=perfluoro-5,10-bis(perfluorophenyl)-5,10-dihydrophenazine). [Fe(CO)5].+[Al(ORF)4]− fully characterized (scXRD analysis, IR, NMR, EPR, 57Fe spectroscopy, CV SQUID m...

Herpes simplex virus type-1 (HSV-1) is a neurotropic pathogen of humans that establishes latent infection in the sensory ganglia innervating the site of primary infection. A number of genes control HSV-1 pathogenicity and latency. Open reading frame P (ORF P) is one of these genes that might have a role in latency and pathogenesis. A complication in the analysis of the role of ORF P in the HSV-...

Orf, a viral zoonotic disease, is transmitted to humans from small ruminants such as sheep or goats. It usually progresses with one more nodular lesions appearing on the dorsal surface of fingers. Orf disease may sometimes present differently its typical location and clinical presentation. Here, we 2 orf cases that occurred after burns. Both patients' family members had history contact The diag...

a complication in the analysis of the role of icp34.5 gene in the herpes simplex virus type-1 (hsv-1) lifecycle is the presence of overlapping antisense gene, open reading frame p (orf p), which is also deleted in hsv-1 icp34.5 negative mutants. a hsv-1 wild type strain (17+) icp34.5/orf p deletion mutant (1716) is totally avirulent in animal models and impaired in a number of in vitro function...