This study examined the isoenzymatic pattern of LDH in the cerebrospinal fluid (CSF) as well as the ratio between the five fractions of LDH among patients with various brain tumours, carcinomatous meningitis and control groups. LDH 1/LDH 2 less than 1 was found significant for carcinomatous meningitis (p less than 0.001) and brain metastases (p less than 0.001). LDH 1/LDH 2 ratio was found to b...

THE DETERMINATION of serum lactate dehydrogenase isoenzymes holds out numerous possibilities in the clinical laboratory aside from the obvious applications in myocardial immfarction and liver disease. An excellent review on different patterims obtained in various diseases can be found in an article by Wr#{243}blewski (1). Richterich et at. (2) describe the patterns found in humami tissues. Neve...

By W. H. STARKWEATHER, H. H. SPENCER AND H. K. ScriocH M AMMALIAN LACTATE DEHYDROGENASE ( LDH ) can be separated into five active fractions.’4 The production of electrophoretic extremes, LDH-1 (H4 ) and LDH-5 ( M4 ), is controlled by the action of two genes.5’#{176}The intermediate fractions ( LDH-2, LDH-3, LDH-4 ) are considered hybrid forms of LDH-1 and LDH-5.5’” Assuming that the hybrids are...

Expression of the Lactate Dehydrogenase (LDH) genes during various stages of spermatogenesis was studied by using a combination of Northern blot analyses and in situ hybridization techniques. These studies have indicated that developmentally programmed expression of all three functional LDH genes occurs during differentiation of germ cells. The LDH/C (ldh-3) gene was expressed exclusively durin...

Lactate dehydrogenase (LDH)-immunoglobulin (Ig) complex has been reported in various diseases (1). Here we describe circulating LDH-IgG complex in a postburn patient; the complex appeared to be related to the progression of burn in this case. A 13-year-old Chinese male was admitted to our hospital with burns over 20% of his body. Some of the relevant laboratory test results and reference interv...

The diagnosis of Creutzfeldt-Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool. CSF LDH levels of patients with CJD (n = 26) were compared with those in other dementias (n = 28). LDH isoenzymes were determined in a subset (n = 9). Total LDH and isoenzyme LDH-1 ...

Purpose: Tumour cells produce energy through glycolysis and lactate dehydrogenase (LDH) is a key part of glycolysis. Elevation of serum LDH may indicate poor prognosis in primary duodenum adenocarcinoma. We aim to explore the prognostic significance of LDH in this disease. Methods and materials: Two hundred forty-four patients diagnosed with primary duodenum adenocarcinoma who were treated at t...

Lactate dehydrogenase (LDH) X has been isolated in crystalline form from mouse testes. Homogeneity of the protein preparation was established by disc gel electrophoresis, analytical ultracentrifugation, and immunochemical analyses. LDH-X is clearly distinct in amino acid composition from LDH-1 and LDH-5 with respect to numbers of residues of leucine, glycine, threonine, and methionine. When 6 t...