Fluorocyclopentenylcytosine (RX-3117) is an orally available cytidine analog, currently in Phase I clinical trial. RX-3117 has promising antitumor activity in various human tumor xenografts including gemcitabine resistant tumors. RX-3117 is activated by uridine-cytidine kinase (UCK). Since UCK exists in two forms, UCK1 and UCK2, we investigated which form is responsible for RX-3117 phosphorylat...

Accumulating evidence suggests that central thyrotropin-releasing hormone (TRH) administration induces gastric erosion 4 h after administration through the vagal nerves. However, early changes in the gastric mucosa during these 4 h have not been described. To assess early changes in the gastric mucosa after intracisternal injection of a stable TRH analog, pGlu-His-(3,3'-dimethyl)-ProNH2 (RX-773...

In this paper we present a nonlinear version of the wellknown anomaly detection method referred to as the RXalgorithm. Extending this algorithm to a feature space associated with the original input space via a certain nonlinear mapping function can provide a nonlinear version of the RX-algorithm. This nonlinear RX-algorithm, referred to as the kernel RX-algorithm, is basically intractable mainl...

Serotonin (5-HT) interacts with thyrotropin-releasing hormone (TRH) at the dorsal vagal complex (DVC) to augment TRH-induced stimulation of gastric acid secretion. To investigate the 5-HT receptor family involved in the augmentation response, prototypical 5-HT receptor-selective agonists (146 pmol) were coinjected with the TRH analog RX-77368 (RX; 12 pmol) into the rat DVC in a 30-nl volume. Th...

This research involves simulating remote sensing conditions using previously collected hyperspectral imagery (HSI) data. The Reed–Xiaoli (RX) anomaly detector is well-known for its unsupervised ability to detect anomalies in hyperspectral images. However, the RX detector assumes uncorrelated and homogeneous data, both of which are not inherent in HSI data. To address this difficulty, we propose...

We report the discovery of two new AM Herculis systems (polars), identified as the optical V∼19 mag and V∼20 mag counterparts of the soft X-ray sources RX J2022.6−3954 and RX J0132.7−6554 detected during the ROSAT All-Sky Survey and present the results of our optical and X-ray follow-up observations. From the cyclotron emission lines detected in the optical spectra we determine magnetic field s...

PURPOSE The goals of stereotactic radiosurgery (SRS) are the ablation of target tissue and sparing of critical normal tissue. We develop tools to aid in the selection of collimation and prescription (Rx) isodose line to optimize the dose gradient for single isocenter intracranial stereotactic radiosurgery (SRS) with GammaKnife 4C utilizing the updated physics data in GammaPlan v10.1. METHODS ...

BACKGROUND Hypothesizing that statins may be useful as adjuvant treatment for renal anemia, we examined the association between statin prescription (Rx) and erythropoiesis-stimulating agent (ESA) hyporesponsiveness in Japanese hemodialysis (HD) patients prescribed ESAs. METHODS We examined 3,602 patients in 60 HD facilities dialyzed 3 times/week for ≥4 months from the Japan Dialysis Outcomes ...