Abstract Background Obsessive–compulsive disorder (OCD) is usually associated with insight’s heterogeneity, and those poor insight showed lower BDNF cognitive deficiencies. The aim was to detect the relation between executive dysfunction BDNF. Materials methods Forty patients diagnosed OCD forty matched healthy controls. Also, both good groups (assessed by Brown Assessment of Belief Scale) were...

The odontoblastic differentiation of dental pulp stem cells (DPSCs) associated with caries injury happens in an inflammatory context. We recently demonstrated that there is a link between inflammation and tissue regeneration, identified via enhanced DPSC-mediated dentinogenesis vitro. Brain-derived neurotrophic factor (BDNF) nerve growth factor-related gene family molecule which functions throu...

brain derived neurotrophic factor (bdnf) is a neurotrophin acting at several levels in the brain. additionally, bdnf was shown to be responsible for the survival, maintenance and growth of neurons. also, bdnf plays an important role in synaptic plasticity and memory processes. in activity-dependent synaptic plasticity, bdnf enhances long-term potentiation (ltp) in the hippocampus but blocks the...

BACKGROUND The human Val66Met polymorphism in brain-derived neurotrophic factor (BDNF), a key factor in neuroplasticity, synaptic function, and cognition, has been implicated in the pathophysiology of neuropsychiatric and neurodegenerative disorders. BDNF is encoded by multiple transcripts with distinct regulation and localization, but the impact of the Val66Met polymorphism on BDNF regulation ...

Depression is a complex psychiatric disorder that significantly impacts millions of individuals worldwide. Despite advances in our understanding its neurobiological underpinnings, treatment options remain limited, and not all patients respond adequately to available therapies. Emerging evidence has implicated brain-derived neurotrophic factor (BDNF), critical regulator neuronal plasticity, the ...

Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and cardiovascular development and function. Recently, a common single nucleotide polymorphism in the bdnf gene, resulting in a valine to methionine substitution in the prodomain (BDNF(Met)), has been shown to lead to memory impairment and susceptibility to neuropsychiatric disorders in humans heterozygous for the ...

The expression of brain-derived neurotrophic factor (BDNF) mRNA and the secretion of BDNF protein are tightly regulated by neuronal activity. Thus, BDNF has been proposed as a mediator of activity-dependent neural plasticity. Previous studies showed that dark rearing (DR) reduces BDNF mRNA levels in the primary visual cortex (V1), but the effects of visual experience on BDNF protein levels are ...

Brain-derived neurotrophic factor (BDNF) polymorphism is associated with the pathophysiology of several neurodegenerative disorders, including Huntington's disease. In view of these data and the involvement of huntingtin in intracellular trafficking, we examined the intracellular transport and release of Val66Val BDNF (Val-BDNF) and Val66Met BDNF (Met-BDNF) in transfected striatal knock-in cell...