نتایج جستجو برای: موتیف ape

تعداد نتایج: 2566  

2005
Eric-Jan Wagenmakers Peter Grünwald Mark Steyvers

This article reviews the rationale for using accumulative one-step-ahead prediction error (APE) as a data-driven method for model selection. Theoretically, APE is closely related to Bayesian model selection and the method of minimum description length (MDL). The sole requirement for using APE is that the models under consideration are capable of generating a prediction for the next, unseen data...

2013
Junmin Song Seiji Futagami Hiroyuki Nagoya Tetsuro Kawagoe Hiroshi Yamawaki Yasuhiro Kodaka Atsushi Tatsuguchi Katya Gudis Taiga Wakabayashi Masaoki Yonezawa Mayumi Shimpuku Yasuhiko Watarai Katsuhiko Iwakiri Yoshio Hoshihara Hiroshi Makino Masao Miyashita Shinichi Tsuchiya Yan Li Sheila E. Crowe Choitsu Sakamoto

Apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzyme responsible for DNA base excision repair (BER), has been linked to cancer chemoradiosensitivity. The phosphorylation of p65 plays a role in the activation of this pathway. In this study, we investigated APE-1 expression and its interaction with p65 in esophageal squamous cell carcinoma (ESCC) tissue. The expression of APE-1, p65, p65 nu...

2013
Haw-Wen Chen Chin-Shiu Huang Pei-Fen Liu Chien-Chun Li Chiung-Tong Chen Cheng-Tzu Liu Jia-Rong Chiang Hsien-Tsung Yao Chong-Kuei Lii

Andrographolide is the most abundant terpenoid of A. paniculata which is used in the treatment of diabetes. In this study, we investigated the effects of A. paniculata extract (APE) and andrographolide on the expression of drug-metabolizing enzymes in rat liver and determined whether modulation of these enzymes changed the pharmacokinetics of tolbutamide. Rats were intragastrically dosed with 2...

Journal: :Bioscience, biotechnology, and biochemistry 2007
Daiki Miura Yutaka Miura Kazumi Yagasaki

The effect of apple polyphenol extract (APE) on the proliferation and invasion of a rat ascites hepatoma cell line of AH109A was examined in vitro. APE suppressed both the hepatoma proliferation and invasion in a dose-dependent manner up to 200 mug/ml. Serum obtained from rats orally given APE also inhibited hepatoma proliferation and invasion when added to the culture medium. Subsequently, the...

Journal: :Surgical oncology clinics of North America 2014
Torbjörn Holm

Abdominoperineal excision (APE) is a necessary operation in many patients with low rectal cancer. Outcomes after this procedure, however, have been variable and often suboptimal. With a new concept of APE, three different types of procedures can be described, based on pelvic and pelvic floor anatomy: intersphincteric APE, extralevator APE (ELAPE), and ischioanal APE. Improved outcomes have been...

این مقاله ،جستاری تحلیلی در چگونگی حضور و کارکرد "موتیف" درچند اثر داستانی در حوزه ی ادبیات کودک و نوجوان است .مباحث نظری این جستار، پیرامون حضورو نقش اساسی موتیف ها در اثار هنری-ادبی و شامل تعاریف و تاریخچه ی مختصری از مطالعات مربوط به این عناصراست. در حوزه ی کاربردی ،پس از مطالعه وبررسی دقیق موتیف ها ی آشنا و سنتی و موتیف های آشنایی زدا و نو،،علاوه بر تحلیل کارکرد ان ها و نمایش ویژگی اصلیشان ...

2015
Zhou Yin Yiyi Chen Qiong Xie Zhexin Shao

BACKGROUND Safe exclusion and risk stratification are currently recommended for the initial management of patients with acute pulmonary embolism (APE). The aim of this study was to assess the safe exclusion and risk stratification value of D-dimer (DD) for APE when tested at the beginning of admission. MATERIALS AND METHODS All consecutive Chinese APE patients and controls were recruited from...

Journal: :Current Biology 2005

Journal: :Performance Research 2015

Journal: :Cardiovascular Ultrasound 2008
Roberto Copetti Gino Soldati Paolo Copetti

BACKGROUND Differential diagnosis between acute cardiogenic pulmonary edema (APE) and acute lung injury/acute respiratory distress syndrome (ALI/ARDS) may often be difficult. We evaluated the ability of chest sonography in the identification of characteristic pleuropulmonary signs useful in the diagnosis of ALI/ARDS and APE. METHODS Chest sonography was performed on admission to the intensive...

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