نتایج جستجو برای: منطقه mena
تعداد نتایج: 67891 فیلتر نتایج به سال:
BACKGROUND The meningococcal serogroup A (MenA) polysaccharide conjugate vaccine used in Sub-Saharan Africa does not prevent disease caused by MenW or MenX strains, which also cause epidemics in the region. We investigated the vaccine-potential of native outer membrane vesicles with over-expressed factor H-binding protein (NOMV-fHbp), which targeted antigens in African meningococcal strains, an...
During tumor progression, alternative splicing gives rise to different Mena protein isoforms. We analyzed how Mena11a, an isoform enriched in epithelia and epithelial-like cells, affects Mena-dependent regulation of actin dynamics and cell behavior. While other Mena isoforms promote actin polymerization and drive membrane protrusion, we find that Mena11a decreases actin polymerization and growt...
UNLABELLED Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here, we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo Haptotaxis on FN gradients requires direct interaction between α5β1 integrin and MENA, an actin regulator, and involves increases in focal complex ...
Drosophila Enabled is required for proper formation of axonal structures and is genetically implicated in signaling pathways mediated by Drosophila AbI. We have identified two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein). A conserved domain targets Mena to localized proteins containing a specific proline-rich motif. Th...
There has been an unprecedented trade liberalization which started in the mid1980s in a wide spectrum of developing countries. In the same period, there have also been considerable changes in the tax structures of countries. This paper uses panel data on 65 countries, including 16 Middle East and North Africa (MENA) countries, for the period 1980–1997 to examine how tax structures responded to ...
To overcome the limited immunogenicity of the meningococcal group A (MenA) polysaccharide (Ps) vaccine, the protein conjugation technology was applied to the development of MenAfriVac® (Serum Institute of India Ltd.). The MenA Ps is covalently conjugated to a protein, which acts as an immunologic carrier. MenAfriVac is a purified MenA polysaccharide tetanus toxoid (TT) conjugated vaccine (10 μg...
مطالعه تجارت درون صنعت برای کشورهایی که در جستجوی مزیتت هتای سست ی وایعتی هستند، با درسظر گرفتن شیوه و تکنولوژی تولید این کشورها، بسیار مهم و حیاتی است. ایتران سیز در راه پیشرفت و توسعه روابط برون متریی تجتاری دتود، سیایمنتد ال تویی مناست بترای تولید و صادرات کالاها و همچنین واردات مواد و کالاهای مورد سیای است. برای رسیدن به این هدف باید بتواسیم به دوبی مزیت های سس ی تجاری را در کشور شناسایی کت...
The objective of this paper is to situate the MENA area within the emerging markets universe. We first discuss the various components of market emergence and generate four bootstrapped indexes reflecting market size, market activity, market pricing and transparency. We then draw inter-regional and country-level comparisons using a probit model and a hierarchical cluster analysis. Our results su...
We have shown previously that distinct Mena isoforms are expressed in invasive and migratory tumor cells in vivo and that the invasion isoform (Mena(INV)) potentiates carcinoma cell metastasis in murine models of breast cancer. However, the specific step of metastatic progression affected by this isoform and the effects on metastasis of the Mena11a isoform, expressed in primary tumor cells, are...
A fluorescent-particle-based multiplex flow cytometric immunoassay (MIA) for the detection of serum immunoglobulin G (IgG) and two IgG subclasses, IgG1 and IgG2, specific for Neisseria meningitidis serogroup A (MenA) and C (MenC) polysaccharides (PS) was developed. The assay comprised three separate duplex assays, one for the detection of the IgG response to MenA and MenC PS, another for the de...
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