Marginal zone (MZ) B cells produce a first wave of antibodies for protection from blood-borne pathogens. However, the role of MZ B cells in inflammatory responses has not been elucidated. Here we show that MZ B cells produce pro-inflammatory cytokines, such as interleukin-6 (IL-6), and exacerbate systemic inflammatory responses to lipopolysaccharide (LPS). After intravenous injection of LPS or ...

We have found that mebendazole (MZ), a derivative of benzimidazole, induces a doseand time-dependent apoptotic response in human lung cancer cell lines. In this study, MZ arrested cells at the G2-M phase before the onset of apoptosis, as detected by using fluorescence-activated cell sorter analysis. MZ treatment also resulted in mitochondrial cytochrome c release, followed by apoptotic cell dea...

Monozygotic (MZ) twins show remarkable resemblance in many aspects of behavior, health, and disease. Until recently, MZ twins were usually called "genetically identical"; however, evidence for genetic and epigenetic differences within rare MZ twin pairs has accumulated. Here, we summarize the literature on MZ twins discordant for Mendelian inherited disorders and chromosomal abnormalities. A sy...

The European Union allows the designation of mixing zones (MZ) adjacent to a punctual discharge. Concentrations one or more substances could exceed environmental quality standards in MZ if rest water body meets standards. However, does not explain how define it. In this paper, simulation is done through two free software, Discharge Test and Visual Plumes. used perform first analysis proposed sc...

I present a way of reconciling gauge coupling unification in minimal supersymmetry with small αs(mZ) ≈ 0.11 and discuss the ensuing consequences. ∗ Talk presented at SUSY-95, 15–19 May, 1995, Ecole Polytechnique, Palaiseau, France. In this talk [1] I would like to make two points: • The value of αs(mZ) resulting from exact gauge coupling unification in the most popular version of the MSSM predi...

BACKGROUND AND AIM: Several risk factors contribute to periodontal diseases. Studying twins has helped increase our knowledge on the roles of genetic and environmental factors in periodontal diseases. The objective of this study was the evaluation of periodontal parameters in the twins of Khorasan Province, Iran. METHODS:...