The disposition and metabolism of pentamethylmelamine (PMM) and hexamethylmelamine (HMM) were studied in the rabbit, and the disposition of PMM was studied in humans. Parent compound and metabolites were identified by thin-layer chromatography, gas chromatography, and gas chromatography/mass spectrometry analyses. Plasma elimination in both species following i.v. administration of each drug was...

We explore generalizations of the pari-mutuel model (PMM), a formalization of an intuitive way of assessing an upper probability from a precise one. We discuss a naive extension of the PMM considered in insurance and generalize the natural extension of the PMM introduced by P. Walley and other related formulae. The results are subsequently given a risk measurement interpretation: in particular ...

In this paper, we proposed a novel probabilistic generative model to deal with explicit multiple-topic documents: Parametric Dirichlet Mixture Model(PDMM). PDMM is an expansion of an existing probabilistic generative model: Parametric Mixture Model(PMM) by hierarchical Bayes model. PMM models multiple-topic documents by mixing model parameters of each single topic with an equal mixture ratio. P...

Giardia lamblia, which is an important parasitic cause of diarrhea, uses activated forms of glucose to make glycogen and activated forms of mannose to make glycophosphosphoinositol anchors. A necessary step for glucose activation is isomerization of glucose-6-phosphate to glucose-1-phosphate by a phosphoglucomutase (PGM). Similarly, a phosphomannomutase (PMM) converts mannose-6-phosphate to man...

While molting occurs in the development of many animals especially in arthropods, postmaturity molting (PMM, organisms continue to molt after sexual maturity) has received little attention. Mechanism of molting has been studied intensively, however, the mechanism of PMM remains unknown although it is suggested to be crucial for the development of body size. In this study, we investigated factor...

The Parallel Mixed Model (PMM) approach is suitable for hit selection and cross-comparison of RNAi screens generated in experiments that are performed in parallel under several conditions. For example, we could think of the measurements or readouts from cells under RNAi knock-down, which are infected with several pathogens or which are grown from different cell lines. PMM simultaneously takes i...

Forest floor mineral soil mix (FMM) and peat mineral soil mix (PMM) are cover soils commonly used for upland reclamation post open-pit oil sands mining in northern Alberta, Canada. Coarse woody debris (CWD) can be used to regulate soil temperature and water content, to increase organic matter content, and to create microsites for the establishment of microorganisms and vegetation in upland recl...

BACKGROUND Progressive myelomalacia (PMM) is a catastrophic disease associated with acute intervertebral disc extrusion (IVDE). Published data on the clinical characteristics of this disease are limited. OBJECTIVE To describe the onset and progression of clinical signs of PMM in a large case cohort. ANIMALS Fifty-one dogs, 18 with histopathologically confirmed PMM, 33 presumptively diagnose...

Phosphomannomutase (PMM; EC 5.4.2.8) is a cytosolic enzyme that catalyzes the reversible conversion of mannose 6-phosphate to mannose 1-phosphate, a substrate for the synthesis of GDP-mannose, which is a nucleotide sugar required in glycosylation. Previously known in yeast (1, 2), Van Schaftingen and Jaeken (3 ) described the enzyme in 1995 in humans and its deficiency in patients with congenit...

Melanopsin (OPN4) is a photoreceptive molecule regulating circadian systems in mammals. Previous studies from our laboratory have shown that co-localized dopamine-melatonin (DA-MEL) neurons in the hypothalamic premammillary nucleus (PMM) are putatively photosensitive and exhibit circadian rhythms in DAergic and MELergic activities. This study investigates turkey OPN4x (tOPN4x) mRNA distribution...