The interstitial fluid pressure (IFP) has been found to be as high as 20 to 50 mm Hg in both experimental and human solid tumors. While the IFP is an important determinant of the delivery of therapeutic agents to neoplastic cells in vivo, the mechanisms responsible for interstitial hypertension are not completely understood. The high vascular permeability of tumor blood vessels and the absence ...

Elevated tumor interstitial fluid pressure (IFP) is believed to be responsible, at least in part, for the poor penetration and heterogeneous distribution of blood-borne therapeutic agents and nutrients in solid tumors. Using the wick-in-needle technique, IFP was measured in human patients with squamous cell carcinoma of the uterine cervix at the initial and final stages of fractionated external...

Cell-based therapies have recently been proposed for the treatment of degenerative articular pathologies, such as early osteoarthritis, with an emphasis on autologous mesenchymal stem cells (MSCs), as an alternative to terminally differentiated cells. In this study, we performed a donor-matched comparison between infrapatellar fat pad MSCs (IFP-MSCs) and knee subcutaneous adipose tissue stem ce...

In this work, we present definition of intuitionistic fuzzy parameterized (IFP ) intuitionistic fuzzy soft set and its operations. Then we define IFP -aggregation operator to form IFP -intuitionistic fuzzy soft-decision-making method which allows constructing more efficient decision processes.

PURPOSE The interstitial fluid pressure (IFP) of the primary tumor is an independent prognostic parameter for cervical cancer patients treated with radiation therapy. The aim of this preclinical study was to investigate whether tumor radiocurability may be associated with IFP through hypoxia-independent mechanisms. EXPERIMENTAL DESIGN Small A-07 and R-18 melanoma xenografts without hypoxic ti...

Inflammatory fibroid polyp (IFP) is a rare solitary gastrointestinal lesion of unknown etiology. It generally presents as polypoid mass in the gastric antrum. Mostly affects adults at average age of 60 years. IFP can cause different symptoms such as abdominal pain, gastrointestinal bleeding, intestinal obstruction or intussusception. IFP is a bening lesion and it may rarely mimic the submucosal...

Interstitial fluid pressure (IFP) is elevated in tumors. This may constitute a significant physiological barrier to drug delivery to solid tumors. Owing to this elevated IFP, the interstitial fluid velocity (IFV) is negligible throughout the tumor but significant near the tumor margin. Any therapeutic strategy that can lower the IFP will likely improve drug convection within the tumor and decre...

BACKGROUND Leishmania tarentolae, a unicellular eukaryotic protozoan, has been established as a novel host for recombinant protein production in recent years. Current protocols for protein expression in Leishmania are, however, time consuming and require extensive lab work in order to identify well-expressing cell lines. Here we established an alternative protein expression work-flow that emplo...

Let Q IFP be any quantiier such that FO(Q IFP), rst order logic enhanced with Q IFP and its vectorizations, equals inductive xed point logic, IFP in expressive power. It is known that for certain quantiiers Q, the equivalence FO(Q IFP) IFP is no longer true if Q is added on both sides 12, 13]. Rather, we have FO(Q IFP ; Q) < IFP(Q) in such cases. We extend these results to a great variety of qu...