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BACKGROUND Natural killer (NK) cells are the effector cells of innate immunity that respond to infection and tumor. Interactions between killer cell immunoglobulin like receptors (KIR) and human leukocyte antigen (HLA) class I molecules regulate NK cells responses to eliminate infected and transformed cells. OBJECTIVE To investigate the impact of KIR genes, HLA ligand genes, and KIR-HLA combi...
BACKGROUND Land Use Regression models (LUR) are useful to estimate the spatial variability of air pollution in urban areas. Few studies have evaluated the stability of spatial contrasts in outdoor nitrogen dioxide (NO₂) concentration over several years. We aimed to compare measured and estimated NO₂ levels 12 years apart, the stability of the exposure estimates for members of a large cohort stu...
BACKGROUND Land use regression (LUR) models have been developed mostly to explain intraurban variations in air pollution based on often small local monitoring campaigns. Transferability of LUR models from city to city has been investigated, but little is known about the performance of models based on large numbers of monitoring sites covering a large area. OBJECTIVES We aimed to develop Europ...
Land use regression (LUR) models have been used to assess air pollutant exposure, but limited evidence exists on whether location-specific LUR models are applicable to other locations (transferability) or general models are applicable to smaller areas (generalizability). We tested transferability and generalizability of spatial-temporal LUR models of hourly particle number concentration (PNC) f...
BACKGROUND Oxidative potential (OP) has been suggested to be a more health-relevant metric than particulate matter (PM) mass. Land use regression (LUR) models can estimate long-term exposure to air pollution in epidemiological studies, but few have been developed for OP. OBJECTIVES We aimed to characterize the spatial contrasts of two OP methods and to develop and evaluate LUR models to asses...
Two approaches have dominated formulations designed to capture small departures from unit root autoregressions. The first involves deterministic departures that include local-to-unity (LUR) and mildly (or moderately) integrated (MI) specifications where departures shrink to zero as the sample size n → ∞. The second approach allows for stochastic departures from unity, leading to stochastic unit...
For indoor air modelling, difficulties in collecting parameters including life activity patterns and building characteristics are dilemmas when conducting a large-area study. Land-use/land cover information which is easier to obtain could represent as surrogates of emission sources for assessing quality. Moreover, low-cost sensors machine learning provide better way enhance model accuracy. This...
Introduction: Killer-cell Immunoglobulin-like Receptors (KIR) are the members of inhibitory and activating receptors expressed chiefly by the natural killer cells (NK). KIR proteins operate as receptors detecting human leukocyte antigen class Ι molecules (HLA). KIRs and their class Ι HLA ligands contribute in the pathogenesis of many kinds of diseases. The aim of this study was to genotypic ana...
تاکنون طرح هایی چند در جهت کاهش آلودگی هوای شهر تهران به مرحله اجراگذاشته شده است. اما مسئله این است که در کنار سایر کاستی ها، این طرح ها اغلب با تبعیت از مدیریت بحران به جای مدیریت ریسک،در واقع عکس العملی منفعلانه ومقطعی در مقابل افزایش آلودگی هوا بوده ودر تصمیمات مدیریتی مبتنی بر این طرح ها از سامانه پشتیبانی تصمیم گیری استفاده نشده است. لذا این پژوهش به سبب اهمیت موضوع با روشی تحلیلی-کاربردی...
Background: Natural killer (NK) cells are the effector cells of innate immunity that respond to infection and tumor. Interactions between killer cell immunoglobulin like receptors (KIR) and human leukocyte antigen (HLA) class I molecules regulate NK cells responses to eliminate infected and transformed cells. Objective: To investigate the impact of KIR genes, HLA ligand genes, and KIR-HLA combi...
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