The ability of anti-chicken smooth-muscle actomyosin y-globulins (anti-GAM) to inhibit the aggregation of dissociated cells from the skeletal muscle and liver of chick embryos was abolished by pretreatment of the anti-GAM with either myosin or heavy meromyosin (HMM). When the same cells were treated with HMM at a concentration of 1 mg per 2x10' cells/ml Eagle's MEM they aggregated as readily as...

Effective methods for metrics definition are of particular importance, as measurement mechanisms are indispensable in virtually any engineering discipline. The paper describes how the well known Goal-Question-Metric (GQM) method of systematic metrics derivation from measurement goals can be extended by applying argument structures. The proposed approach is called Goal-Argument-Metric (GAM). The...

The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous system (CNS). We argue that the role of the CSPGs can be reversed from inhibition to activation by developmentally expressed CSPG-binding factors. Heparin-binding growth-associated molecule (HB-GAM; also designated as pleiotrop...

MicroRNAs (miRNAs) are small regulatory RNAs targeting multiple effectors of cell homeostasis and development, whose malfunctions are associated with major pathologies such as cancer. Herein we show that GAM/ZFp/ZNF512B works within an intricate gene regulatory network involving cell-cycle regulators, TGFβ effectors and oncogenic miRNAs of the miR-17-92 cluster. Thus, GAM impairs the transcript...

The highly invasive and angiogenic characteristics of malignant gliomas depend on the production of growth factors and angiogenic factors. Heparin-binding growth-associated molecule (HB-GAM) is a secreted growth factor that is mitogenic for endothelial cells. To examine the expression profile of HB-GAM in malignant glioma cells, messenger ribonucleic acid (mRNA) expression was analyzed in 10 ma...

GAMs oscillate between states of strong rotation and up-down asymmetric plasma compression. Hence, at first glance the natural turbulent drive (or damping) mechanisms for them is either a direct boost of the rotation – via Reynolds stress – or the creation of asymmetric pressure distributions – via transport. However, an up-down asymmetric pressure can also be created by the divergence of the d...

In this study, per-person municipal expenditures were modeled as a function of six demographic and income-related variables, first using a robust linear regression model (LM), and second using a generalized additive model (GAM). A comparison of the two models revealed that the GAM provided more accurate predictions, and therefore we recommend for the client to use the GAM as the basis for predi...

The geodesic acoustic mode (GAM) is a high frequency branch of zonal flows, which is observed in toroidal plasmas. Because of toroidal curvature effects, density fluctuations are excited, which are investigated with the O-mode correlation reflectometer at TEXTOR. This Letter reports on the poloidal distribution of GAM induced density fluctuation and compares them with theoretical predictions. T...

As an extension of the traditional Land Use Regression (LUR) modelling, the generalized additive model (GAM) was developed in recent years to explore the non-linear relationships between PM2.5 concentrations and the factors impacting it. However, these studies did not consider the loss of information regarding predictor variables. To address this challenge, a generalized additive model combinin...