One,1-dichloro-2,2 bis(p-chlorophenyl) ethylene (p,p'-DDE), the major metabolite of 2,2-bis(4-Chlorophenyl)-1,1,1-trichloroethane (DDT), is a known persistent organic pollutant and male reproductive toxicant. It has antiandrogenic effect. However, the mechanism by which p,p'-DDE exposure causes male reproductive toxicity remains unknown. In the present study, rat Sertoli cells were used to inve...

The chemistry of Mu transposition is executed within a tetrameric form of the Mu transposase (MuA protein). A triad of DDE (Asp, Asp35Glu motif) residues in the central domain of MuA (DDE domain) is essential for both the strand cleavage and strand transfer steps of transposition. Previous studies had suggested that complete Mu transposition requires all four subunits in the MuA tetramer to car...

The Distributed Differential Evolution (dDE) algorithm is a natural extension of the Differential Evolution (DE) algorithm, which is a recent addition to the Evolutionary Algorithms (EAs) pool, in the Evolutionary Computing (EC) field of computer science. The algorithmic novelty of the dDE algorithm is well evident in the literature. However, the theoretical studies on the performance of the dD...

Compiled are abstracts from developmental and reproductive epidemiologic and animal toxicity studies and other relevant investigations. This information was used in a screen to select appropriate chemicals for presentation to the Developmental and Reproductive Toxicant Identification Committee as possible candidates for Committee consideration. The criterion for passing this screen is the exist...

(continued inside) R SUMMARY ecent work by the Centers for Disease Control (CDC) on the leukemia cluster investigation in Churchill County, Nevada found the chemical DDE in relatively high concentrations in urine samples. DDE is produced by natural degradation of the pesticide DDT. The pesticide has been out of use in the United States for more than three decades, but it persists in the environ...

This chapter presents a dynamical systems point of view the study with delays. The focus is on how advanced tools from bifurcation theory, as implemented for example in package DDE-BIFTOOL, can be applied to delay differential equations (DDEs) arising applications, including those that feature state-dependent We discuss present capabilities most recent release DDE-BIFTOOL. They include numerica...

Locations of contaminant exposure for nesting migratory species are difficult to fully understand because of possible additional sources encountered during migration or on the wintering grounds. A portion of the migratory white-faced ibis (Plegadis chihi) nesting at Carson Lake, Nevada continues to be exposed to dichloro-diphenyldichloro-ethylene (DDE) with no change, which is unusual, observed...

The doctrine of double effect (DDE ) is a longstudied ethical principle that governs when actions that have both positive and negative effects are to be allowed. The goal in this paper is to automate DDE. We briefly present DDE , and use a firstorder modal logic, the deontic cognitive event calculus, as our framework to formalize the doctrine. We present formalizations of increasingly stronger ...

the 1950s in Sri Lanka and Guyana. The reports of the Sri Lanka study are not in the peer-reviewed literature. Data from the Guyana sugar plantations must include factors other than DDT and malaria because profound differences existed in all-cause mortality in adults and children over the span of the reports. Whether DDT was effective in those areas at that time cannot determine whether it woul...

Results of serum PBB determinations on 524 Michigan diary farm residents and consumers of products from the farms, 55 chemical workers, and 56 Wisconsin farm residents are reported. Mean and median values were highest for the chemical workers, followed by consumers from and residents of quarantined and nonquarantined farms. Serum DDE was higher among chemical workers, but was similar for all ot...