Editor's Note: This article contains the official text of the MSIS 2000 model curriculum as approved by both the Association for Computing Machinery and the Association for Information Systems. It is presented here in its original form. This copyrighted material may not be reproduced, transmitted, translated, nor stored, in whole or in part, by any means, electronic or mechanical, including pho...

BACKGROUND This study examined whether MS patients and proxy respondents agreed on change in disease impact, which was induced by treatment. This may be of interest in situations when patients suffer from limitations that interfere with reliable self-assessment, such as cognitive impairment. METHODS MS patients and proxies completed the Multiple Sclerosis Impact Scale (MSIS-29) before and aft...

BACKGROUND Inherited defects in the DNA mismatch repair system lead to increased loss or gain of repeat units in microsatellites, commonly referred to as microsatellite instability (MSI). MSIs in coding regions of critical genes contribute to the pathogenesis of DNA-mismatch repair-deficient cancers, particularly those associated with the hereditary nonpolyposis colorectal cancer syndrome (HNPC...

OBJECTIVES To study the effects of whole-body cryostimulation (WBC) on fatigue and functional status in multiple sclerosis (MS) patients with different levels of fatigue. SUBJECTS AND METHODS Two groups of 24 MS patients with fatigue were studied. At the beginning of the study, the first group presented a Fatigue Severity Scale (FSS) score between 38 and 42 (low-fatigue (LF) group), and the s...

BACKGROUND AND AIM The psychometric properties of rating scales are sample dependent and need evaluations in different samples. The Multiple Sclerosis Impact Scale (MSIS-29), a new patient based rating scale for multiple sclerosis (MS) was predominantly developed from a community based sample derived from the MS Society. A number of important patient characteristics of this sample remain unknow...

OBJECTIVES To develop a patient-based, disease-specific measure of the health impact of multiple sclerosis (MS) for use in clinical trials and clinical practice. DATA SOURCES People with MS. Members of the MS Society of Great Britain and Northern Ireland. METHODS Standard psychometric methods were used to develop the Multiple Sclerosis Impact Scale (MSIS-29) in three stages. Stage 1 (item g...

The purpose of this empirical study is to investigate two things: a) the impact domestic economic activities falling sharply due COVID-19 pandemic on micro and small industries (MSIs) throughout 2020, (b) forms crisis mitigation measures (CMMs) adopted by crisis-affected MSIs. evaluates importance four components, namely capital, collaboration, cooperation, digital technology (DT), using data f...

Multiple sclerosis (MS) is a chronic disease of central nervous system. The multiple sclerosis information system (MSIS), such as other information system (IS), depends on identification, collection and processing of data for producing useful information. Lack of the integrated IS for collecting standard data causes undesirable effects on exchanging, comparing, and managing. The aim of this stu...