Alexandros Linos1, Alexander Steinbüchel2 1 Institut für Mikrobiologie, Westfälische Wilhelms-Universität Münster, Corrensstraûe 3, 48149 Münster, Germany; Tel. :‡49-251-8339821; Fax:‡49-251-8338388; E-mail : [email protected] 2 Institut für Mikrobiologie, Westfälische Wilhelms-Universität Münster, Corrensstraûe 3, 48149 Münster, Germany; Tel. :‡49-251-8339821; Fax:‡49-251-8338388; E-mail ...

Metastatic melanoma is an aggressive cancer with very low response rate against conventional chemotherapeutic agents such as dacarbazine (DTIC). Inhibitor of Rb-Raf-1 interaction RRD-251 was tested against the melanoma cell lines SK-MEL-28, SK-MEL-5, and SK-MEL-2. RRD-251 was found to be a potent inhibitor of melanoma cell proliferation, irrespective of V600E B-Raf mutation status of the cell l...

This study was designed to investigate the association of the IL-8-251 T > A gene polymorphism with clinicopathological features and the prognostic role of the gene polymorphism in patients with gastric adenocarcinoma. The gene polymorphism was detected by the polymerase chain reaction-restriction fragment length polymorphism method, followed by univariate and multivariate analyses to elicit it...

1 Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital Maastricht, Maastricht, The Netherlands 2 Department of Epidemiology, Maastricht University, Maastricht, The Netherlands 3 Department of Health Organization Policy and Economics, Maastricht University, Maastricht, The Netherlands 4 Care and Public Health Research Institute, Department of General Practic...

Metastatic melanoma is an aggressive cancer with very low response rate against conventional chemotherapeutic agents such as dacarbazine (DTIC). Inhibitor of Rb–Raf-1 interaction RRD-251 was tested against the melanoma cell lines SK-MEL-28, SK-MEL-5, and SK-MEL-2. RRD-251 was found to be a potent inhibitor of melanoma cell proliferation, irrespective of V600E B-Raf mutation status of the cell l...

Moral text processing was used as an ecologically valid method for assessing implicit and explicit moral understanding and development. The authors tested undergraduates, seminarians, and graduate students in political science and philosophy for recall of moral narratives and moral expository texts. Multivariate analyses of covariance using educational experience as an independent variable, age...