BACKGROUND Patients with diabetes mellitus and cardiovascular disease may not achieve adequate low-density lipoprotein cholesterol (LDL-C) lowering on statin monotherapy, attributed partly to atherogenic dyslipidemia. More intensive LDL-C-lowering therapy can be considered for these patients. A previous randomized, controlled study demonstrated greater LDL-C lowering in diabetic patients with s...

Purpose: To assess the effect of acupuncture on the electromyographic activity of masticatory muscles in patients with temporomandibular disorder (TMD). Methods: Forty women, from 20 to 40 years old, with TMD diagnosis were assessed using the electromyography of the masseter and temporal (anterior fascicle) muscles. Participants were distributed into study group (SG), which received acupuncture...

The characteristics of rainfall-runoff are important aspects of hydrological processes. In this study, rainfall-runoff processes and soil moisture dynamics at different soil depths and slope positions of grassland with two different row spacings (5 cm and 10 cm, respectively, referred to as R5 and R10) were analyzed, by means of a solution of rainfall simulation experiments. Bare land was also ...

BACKGROUND The main objective of this randomized, double-blind, parallel-group, comparative study was to assess the efficacy and safety of rupatadine 10 mg (R10) and 20 mg (R20) administered once-daily for two weeks compared with those of loratadine 10 mg (L10) in the treatment of seasonal allergic rhinitis (SAR). METHODS A total of 339 SAR patients were randomized to receive R20 (111 patient...

A bank of mouse monoclonal antibodies has been produced with reactivity to gonococcal pili to investigate epitopes of the pilus structural protein, pilin. Pili of Neisseria gonorrhoeae strains R10 and MS11 were used as immunogens to elicit 19 monoclonal antibodies reactive with the homologous pili type in ELISA. Of the 19 antibodies, 16 demonstrated type-specific reactivity and 3 were cross-rea...

Nucleic acid ligands, aptamers, harbor the unique characteristics of small molecules and antibodies. The specificity and high affinity of aptamers enable their binding to different targets, such as small molecules, proteins, or cells. Chemical modifications of aptamers allow increased bioavailability. A further great benefit of aptamers is the antidote (AD)-mediated controllability of their eff...

We study the behavior of matrix string theory in the strong coupling region, where it is expected to reduce to discrete light-cone type IIA superstring. In the large N limit, the reduction corresponds to the double-dimensional reduction from wrapped supermembranes on R10× S1 to type IIA superstrings on R10 in the light-cone gauge, which is shown classically, however it is not obvious quantum me...

OBJECTIVE To evaluate the cost-effectiveness of generic atorvastatin 20 mg (A20), branded rosuvastatin 10 mg (R10), generic simvastatin 40 mg (S40) and the combination of generic S40 + branded ezetimibe 10 mg (S40 + EZ10) for the secondary prevention of coronary heart disease (CHD) in Finnish patients not meeting the target goal of low-density lipoprotein cholesterol (LDL-C) with S40. RESEARC...