One of the top-selling medicinal products worldwide is Hypericum perforatum (St. John's Wort). Despite its cosmopolitan distribution and utilization, little is known regarding the relationship of the bioactive compounds in H. perforatum to the plants from which they are purportedly derived. In this study, amplified fragment length polymorphism (AFLP) analysis of 56 Hypericum accessions, represe...

The present study has been evaluated the neuroprotective effect of Hypericum perforatum extract on the reaction of astrocytes in mice brain treated with an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg with 2 hr intervals). Treatment with Hypericum perforatum extract (HPE) resulted in an inhibition of monoamine oxidase-B (MAO-B) activity and reduced ...

BACKGROUND Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis. METHODS Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was admi...

Since ancient times, the essential oils (EOs) of many aromatic plants have been used as bioactive ingredients in drug, food and cosmetic formulations all over the world. Significant biological properties have also been attributed to Hypericum EOs. Hypericum is a genus of about 450 species in the Guttiferae family, formerly often treated separately in their own Hypericaceae family. Despite the l...

The dried aerial parts of Hypericum perforatum, gathered during the flowering period or shortly before, are used medicinally. The generic name of the herb derives from the Greek meaning to ‘overcome an apparition’ and in earlier times homes would have a plant hanging over the door to ward off evil spirits. This species of hypericum (H. perforatum) is referred to as perforate St John’s wort due ...

St. John's wort (Hypericum perforatum) has been used as a medical herb for over 2000 years. Over the past two decades, its application as a standardized plant extract for treating depression has undergone rigorous scientific investigation, and its effectiveness has been shown in studies comparing it with other commonly used antidepressants and placebos. Safety and tolerability studies have reve...

background & aim: st john's wort (hypericum perforatum l.) contains hypericin and hyperforin as the main components of the extract that binds with gaba and sigma opioid receptors. this herb has many pharmacological effects, including analgesic, sedative, soothing, antispasmodic, anticonvulsant, anti-depressant, and anti-bacteria. in this study examined the effect of two concentrations of hy...

The primary goal of the present study aimed to evaluate the prophylactic effect of Hypericum Perforatum L. extract on memory dysfunction induced by scopolamine in adult male albino rats (Rattus norvegicus Berkenout). Rats administered daily P.O Hypericum Perforatum L. extract (350 mg/kg) for two, four, eight weeks and the group of rats at the end of each interval intraperitoneally administered ...