PURPOSE To review the efficacy of the pattern electroretinogram (PERG) in early diagnosis of glaucoma. METHODS Stimulation parameters of check size and temporal frequency are considered. Analyses of various peaks (P50, N95, the N95/P50) and Fourier steady-state are considered. The relation to visual field defects is explored. RESULTS The PERG is markedly alterated in glaucoma. It shows ampl...

BACKGROUND To assess the sensitivity and specificity of hemifield pattern electroretinogram (HF-PERG) for detecting early retinal ganglion cell (RGC) damage in ocular hypertensive (OH) patients. METHODS Fifty-two OH patients (mean age 56±9.6 years) with an intraocular pressure (IOP) .21 mmHg were assessed. All subjects underwent HF-PERG, optical coherence tomography (OCT), and frequency doubl...

OBJECTIVE To evaluate variability of steady-state pattern electroretinogram (SS-PERG) signal in normal, suspected, and glaucomatous eyes. METHODS Twenty-one subjects with suspected glaucoma due to disc abnormalities (GS), 37 patients with early glaucoma (EG), and 24 normal control (NC) were tested with spectral-domain optical coherence tomography (SD-OCT), standard automated perimetry (SAP), ...

PURPOSE Pattern electroretinography (PERG) is a specific test for the analysis of functions of the central retina. In this study, we investigated the PERG recordings in subjects with myopia. SUBJECTS AND METHODS This study was performed on 1 eye of 80 subjects with varying degrees of myopia. Four groups were formed according to the refraction values: group 1: between 0.00 and -0.75 diopter (D...

Purpose: To evaluate functional and structural deficits in a canine model of compressive optic neuropathy (CON). Methods: CON was induced in healthy beagles by implanting a silicone implant into the orbit and inducing optic nerve compression for 24 hours. Retinal nerve fiber layer (RNFL) thickness was evaluated using optical coherence tomography (OCT). Pattern electroretinography (pERG) was per...

BACKGROUND AND PURPOSE Our study aims to evaluate retinal function and neural conduction in post-retinal visual pathways of patients with non-arteritic ischaemic optic neuropathy (NION). METHODS Twenty patients (mean age: 63.7 +/- 5.96 year) with NION and 20 age-similar control subjects were enrolled. Simultaneous recording of pattern electroretinograms (PERGs) and visual evoked potentials (V...

PURPOSE The conversion rate from untreated ocular hypertension (OHT) to glaucoma is only approximately 1% per year. Discrimination of nonconverters and potential converters would help reserve preventative treatment for those who need it and thus avoid unnecessary side effects and expenditure for those who do not. This prospective study was designed to assess the pattern electroretinogram (PERG)...

PURPOSE To determine retinal pathway origins of pattern electroretinogram (PERG) in macaque monkeys using pharmacologic dissections, uniform-field flashes, and PERG simulations. METHODS Transient (2 Hz, 4 reversals/s) and steady state (8.3 Hz, 16.6 reversals/s) PERGs and uniform-field ERGs were recorded before and after intravitreal injections of L-AP4 (not APB) (2-amino-4-phosphonobutyric ac...

The pattern electroretinogram (PERG) was used to measure the visual acuity and refractive state of nine American kestrels (Falco sparverius). Visual acuity was determined from psychometric functions of PERG amplitude vs. spatial frequency. Refractive state was measured by finding the trial lens that resulted in the highest acuity. All nine kestrels were found to be emmetropic. Their median visu...

ERG and VEP responses to counterphase checkerboard stimuli were obtained from cynomolgus monkeys with monocular glaucoma induced by laser photocoagulation of the trabecular meshwork. The glaucomatous eyes showed reductions of PERG amplitude that were directly related to the histologically defined nerve damage. VEP amplitudes were also reduced in the glaucomatous eyes, but were more variable and...