نتایج جستجو برای: شبکه rtk
تعداد نتایج: 37584 فیلتر نتایج به سال:
The herpes simplex virus thymidine kinase/ganciclovir (HSV TK/GCV) system is one of the best studied cancer suicide gene therapy systems. Our previous study showed that caspase 3 expression was upregulated and bladder tumor growth was significantly reduced in rats treated with a combination of Bifidobacterium (BF) and HSV TK/GCV (BF-rTK/GCV). However, it was raised whether the BF-mediated recom...
ارتقای بازدارندگی دفاعی مستلزم تولید گسترده و متنوع محصولات تجهیزات نظامی است که نیازمند به‌کارگیری ظرفیت‌ها قابلیت‌های وسیع صنعتی است. ازآنجاکه تصدی تملک همه این قابلیت‌ها منطقی اقتصادی نیست، بخشی از فعالیت‌های تولیدی در صنایع دفاعی، برون‌سپاری می‌شود به ایجاد شبکه بزرگی تأمین‌کنندگان منجر شده گستردگی شبکه، تعاملات همکارانه بهبود عملکرد زنجیره تأمین را یک چالش جدی برای مدیران تبدیل کرده سازما...
Multiple myeloma (MM) is a plasma cell disorder that is characterized by a great genetic heterogeneity. Recent next generation sequencing studies revealed an accumulation of tumor-associated mutations in receptor tyrosine kinases (RTKs) which may also contribute to the activation of survival pathways in MM. To investigate the clinical role of RTK-mutations in MM, we deep-sequenced the coding DN...
The single base real-time kinematic (RTK) positioning technique is distance-dependent in terms of accuracy and reliability of the integer ambiguity resolution. The Network RTK (NRTK) technique has been developed to overcome this limitation, so is able to be used over longer distances than is possible with single base RTK whilst maintaining centimetre-level accuracy. This multiple reference stat...
Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the inhibited receptor. To uncover common and unique features in the signaling networks of RTKs, we measured time-dependent signaling in six isogenic ce...
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single drug therapy. Reprogramming of the RTK network leading to alteration in RTK co-expression in response to drug intervention is a dynamic mechani...
Glioblastoma multiforme (GBM) and the mesenchymal GBM subtype in particular are highly malignant tumors that frequently exhibit regions of severe hypoxia and necrosis. Because these features correlate with poor prognosis, we investigated microRNAs whose expression might regulate hypoxic GBM cell survival and growth. We determined that the expression of microRNA-218 (miR-218) is decreased signif...
UNLABELLED Targeted therapy for metastatic colorectal carcinoma consists of anti-EGFR therapy for patients with RAS/RAF wild-type tumors. However, the response rate remains low, suggesting the presence of alternative drivers possibly also representing potential therapeutic targets. We investigated receptor tyrosine kinase (RTK) alterations and MAP2K1 (MEK1) mutations in a large cohort of colore...
The receptor tyrosine kinase (RTK) gene family, involved primarily in cell growth and differentiation, comprises proteins with a common enzymatic tyrosine kinase intracellular domain adjacent to a transmembrane region. The amino-terminal portion of RTKs is extracellular and made of different domains, the combination of which characterizes each of the 20 RTK subfamilies among mammals. We analyze...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید