Ketoconazole (KZ), an imidazole antifungal, was formulated into inclusion complexes via coprecipitation and kneading with β-cyclodextrin (β-CD) as a carrier in 1:1 and 1:2 drug to carrier ratios. The KZ-β-CD solid complexes were characterized by X-ray diffraction and differential scanning calorimetry (DSC). The diffraction pattern of the pure drug revealed the drug to be highly crystalline in n...

Ketoconazole (KZ) is used widely for treating the superficial, systemic fungal activities and hyperandrogenemic states. Its uses are limited by its deleterious effect on histological structure and function of the adrenal cortex. This study investigates whether vitamin D3 supplement can ameliorate the morphological changes induced by KZ. Thirty four adult male albino rats were randomized into co...

Contrast-enhanced MRA methods which provide temporal information, such as the 3D-TRICKS technique[1], have tradeoffs between temporal resolution and spatial resolution[2]. Acquiring data with adequate temporal resolution often limits the achievable spatial resolution. It is desirable to have high in-plane resolution along with good temporal resolution. Recently we have shown that angularly unde...

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The isolation of vitamin Kz as a yellow crystalline compound melting at 53.5-54.5” has recently been reported from this laboratory (McKee, Binkley, MacCorquodale, Thayer, and Doisy, 1939; McKee, Binkley, Thayer, MacCorquodale, and Doisy, 1939). From the analytical data it was impossible to decide definitely on a formula for vitamin Kz. The formula C&H5402 was used for all calculations, although...

We show that for integers k ≥ 2 and n ≥ 3, the diameter of the Cayley graph of SLn(Z/kZ) associated to a standard two-element generating set, is at most a constant times n ln k. This answers a question of A. Lubotzky concerning SLn(Fp) and is unexpected because these Cayley graphs do not form an expander family. Our proof amounts to a quick algorithm for finding short words representing element...

Summary The objective of this study is to improve understanding the geostatistics vertical (bed-normal) permeability (kz) and its influence on reservoir performance during CO2 enhanced oil recovery (EOR) storage. kz scrutinized far less often than horizontal (kx, ky) in most geological modeling. However, our work indicates that it equally important understand characteristics better evaluate the...