BACKGROUND Continuous performance tasks (CPTs) embedded in a virtual reality (VR) classroom environment have been shown to be a sensitive and user-friendly assessment tool to detect cognitive deficits related to attention-deficit/hyperactivity disorder (ADHD). The aim of the current study was to compare the performance of children with ADHD on a VR-CPT while on and off treatment with methylphen...

PURPOSE To evaluate the pharmacokinetics and tissue disposition of macromolecular camptothecin (CPT) drug conjugate, XMT-1001, and irinotecan (CPT-11) in mice bearing HT-29 xenograft tumors. EXPERIMENTAL DESIGN The antitumor efficacy of XMT-1001 was evaluated in the mouse HT-29 human colon carcinoma xenograft model. XMT-1001 was administered intravenously to female athymic nude (nu/nu) mice b...

Objectives-Carnitine palmitoyltransferase (CPT) deficiency is one of the most common defects of mitochondrial fatty acid oxidation. Two different enzymes (CPT-I and CPT-II) are involved. Due to problems in measuring enzyme activity, relatively little is known about the substrate specificity of each of the human enzymes. This is of considerable importance in the treatment of patients. The object...

In a previous study, we established camptothecin (CPT)-resistant cell lines, A549/CPT and HT-29/CPT, from human lung cancer A549 and human colon cancer HT-29. A549/CPT was shown to express similar amounts of DNA topoisomerase I (topo I) as the parental line, and HT-29/CPT was shown to express lower amounts of topo I than its parental line. DNA topoisomerases I and II are known to be functionall...

Amphiphilic Ru(bpy)32+ complex (DC17Ru)—citratoperoxotitanate (CPT) —ditetradecylviologen (DC14V) triad nano-film was fabricated on quartz slab optical waveguide by organic-inorganic hybrid Langmuir-Blodgett method. Transient phosphorescence of the DC17Ru monolayer at 610 nm excited 532 pulsed laser observed SOWG spectroscopy. The partly quenched CPT layer and quenching enhanced DC14V underneat...

It is known that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a semisynthesized derivative of camptothecin (CPT), has a potent antitumor activity in vivo, but 7-ethyl-10-hydroxycamptothecin (SN-38), a metabolite of CPT-11, shows much stronger cytotoxicity in vitro than CPT-11. In this study, we demonstrated that the relaxation of SV40 DNA plasmids by type I DNA to...

II Abstract ABSTRACT Miniature passive atomic frequency standard based on CPT resonance has been drawing more and more attentions in the fields of GPS, underwater navigation, unmanned vehicles, etc. This work focused on improving frequency stability of the CPT atomic frequency standard, and we have mainly carried out the study through two approaches: to reduce CPT signal linewidth by combining ...

Camptothecin (CPT) has anticancer activity. While only the lactone form of CPT is biologically active, this form exhibits poor aqueous solubility. Pharmaceutical formulation of CPT incorporated in liposomes is of significant importance to develop the therapeutic utilization of CPT. The aim of this study was to increase incorporation efficiency and stability of CPT in liposomes composed of hydro...

The successful treatments of brain tumors and many other brain disorders have been limited due to the presence of barricade from microvascular endothelium called the blood-brain barrier (BBB). It was estimated that over 98% of newly developed pharmaceutical drugs do not cross the BBB; therefore, it is necessary to develop methods to improve the delivery of drugs to the brain. In this investigat...