Intention in this review is to present a picture of 1,4-benzodiazepine with particular attention to their reactions and uses in synthetic organic chemistry. Some of these reactions have been applied successfully to the synthesis of biologically important compounds. The main purpose of this review is to present a survey of the literature on 1,4-benzodiazepine chemistry.

The pattern of transposition of Ac from the mutable allele bz-m2(Ac) has been investigated. Stable (bz-s) and finely spotted (bz-m(F)) exceptions were selected from coarsely spotted bz-m2(Ac) ears. The presence or absence of a transposed Ac (trAc) in the genome was determined and, when present, the location of the trAc was mapped relative to the flanking markers sh and wx. The salient general f...

Benzidine (Bz) is a known human carcinogen. Several azo dyes have been synthesized with Bz. Bz can be metabolically released from azo dyes. In a group of Indian workers producing Bz and azo dyes the presence of hemoglobin (Hb) adducts was investigated. The following Hb adducts were identified and quantified by GC-MS: Bz, N-acetylbenzidine (AcBz), 4-aminobiphenyl (4ABP), aniline. 4ABP and anilin...

Severe storms (Dst) and Forbush decreases (FD) during cycle 23 showed that maximum negative Dst magnitudes usually occurred almost simultaneously with the maximum negative values of the Bz component of interplanetary magnetic field B, but the maximum magnitudes of negative Dst and Bz were poorly correlated (+0.28). A parameter Bz(CP) was calculated (cumulative partial Bz) as sum of the hourly n...

BACKGROUND Peri-infarct border zone (BZ) as quantified by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (MRI) has been proposed as a risk stratification tool, and is associated with increased mortality. BZ has been measured by various methods in the literature. We assessed which BZ analysis best predicts inducible arrhythmia during electrophysiological study (EPS). M...

The Ds(Dissociation)-suppressed bronze mutant bz-m2(DI), which is extremely stable in the absence of the regulatory element Ac (Activator), becomes both somatically and germinally unstable when Ac is present. Instability in the germ line may result in the generation of stable (Ac-nonresponding), colored Bz' derivatives. The characterization of several properties of the Bz-controlled enzyme UDPg...

BACKGROUND Benzodiazepines (BZs) are among the most frequently prescribed drugs with the potential for abuse. Young adults ages 18-29 report the highest rates of BZ misuse in the United States. The majority of club drug users are also in this age group, and BZ misuse is prevalent in the nightclub scene. BZ dependence, however, is not well documented. This paper examines BZ dependence and its co...

Multiple myeloma (MM), the second most common hematopoietic malignancy, remains an incurable plasma cell (PC) neoplasm. While the proteasome inhibitor, bortezomib (Bz) has increased patient survival, resistance represents a major treatment obstacle as most patients ultimately relapse becoming refractory to additional Bz therapy. Current tests fail to detect emerging resistance; by the time pati...