Many cytological studies on medullary thyroid carcinoma (MTC) have been reported; however, such studies in large series of patients with MTC have not been performed. We investigated MTC at a single institution in Japan using fine-needle aspiration cytology (FNAC), and aimed to establish a preoperative diagnostic algorithm for MTC. FNAC was performed in 119 of 149 patients with MTC (79.9%) who u...

With a great variety of potential applications, machine-type communications (MTC) is gaining a tremendous interest from mobile network operators and research groups. MTC is standardized by the 3rd Generation Partnership Project (3GPP), which has been regarded as the promising solution facilitating machine-to-machine communications. In the latest standard, 3GPP proposes a novel architecture for ...

Medullary thyroid carcinoma (MTC), which originates from thyroid parafollicular C cells, accounts for 3 to 5% of thyroid malignancies. MTC occurs either sporadically or in an inherited autosomal dominant manner. Hereditary MTC occurs as a familial MTC or as a part of multiple endocrine neoplasia (MEN) type 2A and B syndromes. A strong genotype-phenotype correlation has been observed between her...

MeduIIary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new mutation familial case is important for future clinical management of both the patient and family. The susceptibility gene for hereditary MTC is the RET proto-oncogene. DNA analysis for g...

Medullary thyroid cancer (MTC) is a relatively uncommon yet prognostically significant thyroid cancer. Several recent advances in the biology and current or potential treatment of MTC are notable. These include a new understanding of the developmental biology of the thyroid C cell, which heretofore was thought to develop from the neural crest. RET, encoded by the most common driver gene in MTC,...

The interannual variability of occurrence of multiple tropical cyclone (MTC) events during June–October in the western North Pacific (WNP) was examined for the period 1979–2006. The number of the MTC events ranged from 2 to 9 per year, exhibiting a remarkable year-to-year variation. Seven active and seven inactive MTC years were identified. Compared to the inactive years, tropical cyclone genes...

Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer of thyroid C-cells, for which few treatment options are available. We have recently reported a role for cyclin-dependent kinase 5 (CDK5) in MTC pathogenesis. We have generated a mouse model, in which MTC proliferation is induced upon conditional overexpression of the CDK5 activator, p25, in C-cells, and arrested by interrupting p25 ov...

Medullary thyroid cancer (MTC) is a rare neuroendocrine tumour that originates from the parafollicular cells of the thyroid gland. The most common presentation of MTC is with a single nodule; however, by the time of diagnosis, most have spread to the surrounding cervical lymph nodes. Cushing's syndrome is a rare complication of MTC and is due to ectopic adrenocorticotrophic hormone (ACTH) secre...

Falls during walking are a major cause of injury and death in the elderly. From a falls perspective, a critical gait event is minimum toe clearance (MTC), as failure to achieve foot-ground clearance results in a trip and potentially a fall. MTC exhibits stride-to-stride variability, which must be minimised to avoid the occurrence of toe-ground contact events. Gait kinematics were acquired from ...