Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds leptin. Leptin is an obesity-associated peptide hormone overexpressed in gestational trophoblastic disease (GTD). GTD encompasses several placental abnormalities that range from benign to malignant. Among GTD, molar placentas are characterized by excess proliferation, whereas gestational trophoblastic neopl...

BACKGROUND The use of obstetric ultrasound in the diagnosis of gestational trophoblastic disease (GTD) in high-income settings is well established, leading to prompt management and high survival rates. Evidence from low-income settings suggests ultrasound is essential in identifying complicated pregnancies, but with limited studies reviewing specific conditions including GTD. OBJECTIVE The ai...

OBJECTIVE The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS We conducted a retrospective study of 126 patients with GTD who were treated between 2000 and 2013. A total of 7...

OBJECTIVE The goal of this study was to investigate whether gestational trophoblastic disease (GTD) and healthy pregnancy differ with respect to complete blood count parameters and these parameters can be used both to explain the pathophysiologic mechanisms and differentiate the two conditions from each other. METHODS The data obtained from 37 women with GTD and 61 healthy pregnancies (contro...

Simulation is helpful for evaluating the performances of inspection techniques and requires the modeling of waves scattering from defects. Two classical flaw scattering models have been previously evaluated and implemented in the CIVA platform developed by CEA/LIST to deal with planar defects: the geometrical theory of diffraction (GTD) and the Kirchhoff approximation (KA). These two approaches...

Introduction: Gestational trophoblastic disease (GTD) consists of group of disorders having pathology of abnormal trophoblastic proliferation ranging from hydatidiform mole to gestational trophoblastic neoplasia. Based on differences in morphology, histopathology, karyotype and clinical features, hydatidiform mole can be categorized into partial and complete moles. Molar pregnancy incidence var...

We start by studying the Goldberger-Treiman discrepancy (GTd) ∆ = (2.259± 0.591)%. Then we look at the πN σ term, with the dimensionless ratio σN/2mN = 3.35%. Finally we return to predicting (via the quark model) the πN coupling constant, with GTd ∆ → 0 as mq → mN/3. PACS: 12.39.Ki, 12.39.Mk, 13.25.-k, 14.40.-n Given the recent new value of the πNN coupling constant [1] g πNN/4π = 13.80± 0.12 o...

We start by studying the Goldberger-Treiman discrepancy (GTd) ∆ = (2.259± 0.591)%. Then we look at the πN σ term, with the dimensionless ratio σN/2mN = 3.35%. Finally we return to predicting (via the quark model) the πN coupling constant, with GTd ∆ → 0 as mq → mN/3. Given the recent new value of the πNN coupling constant [1] g πNN/4π = 13.80± 0.12 or gπNN = 13.169± 0.057, (1) along with the ob...