نتایج جستجو برای: سطوح آمادگی فناوری trl

تعداد نتایج: 56845  

Journal: :Journal of the National Cancer Institute 2014
Seiji Mabuchi Yuri Matsumoto Mahiru Kawano Kazumasa Minami Yuji Seo Tomoyuki Sasano Ryoko Takahashi Hiromasa Kuroda Takeshi Hisamatsu Aiko Kakigano Masami Hayashi Kenjiro Sawada Toshimitsu Hamasaki Eiichi Morii Hirohisa Kurachi Nariaki Matsuura Tadashi Kimura

BACKGROUND Tumor-related leukocytosis (TRL) is occasionally found in patients with nonhematopoietic malignancies. We investigated the clinical implication of TRL and individualized treatment for TRL-positive cervical cancer, as well as the underlying biological mechanism. METHODS Clinical data from 258 cervical cancer patients treated with definitive radiotherapy were analyzed to investigate ...

Journal: :Biochimica et biophysica acta 2005
John R Burnett Dawn E Telford P Hugh R Barrett Murray W Huff

Previously, we have shown, in vivo, that the acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor avasimibe decreases hepatic apolipoprotein (apo) B secretion into plasma. To test the hypothesis that avasimibe modulates postprandial triglyceride-rich lipoprotein (TRL) metabolism in vivo, an oral fat load (2 g fat/kg) containing retinol was given to 9 control miniature pigs and to 9 ani...

Journal: :American journal of physiology. Endocrinology and metabolism 2004
Doru V Chirieac Heidi L Collins Joanne Cianci Janet D Sparks Charles E Sparks

Triglyceride-rich lipoprotein (TRL) production was studied in Zucker diabetic fatty (ZDF) rats, a model of insulin-resistant type 2 diabetes progression. TRL production was measured in vivo by blocking catabolism with Triton WR-1339. Ten-week ZDF rats are hyperinsulinemic with increased TRL production [both triglyceride and apolipoprotein B (apoB)]. Twenty-week ZDF rats are insulinopenic, and T...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
M L Hibbert R L Stouffer D P Wolf M B Zelinski-Wooten

Progesterone receptors appear in granuloma cells of preovulatory follicles after the midcycle gonadotropin surge, suggesting important local actions of progesterone during ovulation in primates. Steroid reduction and replacement during the gonadotropin surge in macaques was used to evaluate the role of progesterone in the ovulatory process. Animals received gonadotropins to induce development o...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 1998
J R Burnett P H Barrett P Vicini D B Miller D E Telford S J Kleinstiver M W Huff

We have previously shown in vivo that the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin decreases hepatic apolipoprotein B (apoB) secretion into plasma. To test the hypothesis that atorvastatin modulates exogenous triglyceride-rich lipoprotein (TRL) metabolism in vivo, an oral fat load (2 g fat/kg body wt) containing retinol (50 000 IU) was given to 6 control miniature ...

2015
Rosana Cabello-Moruno Laura Sinausia Kathleen M Botham Emilio Montero Michael Avella Javier S. Perona

Postprandial triacylglycerol-rich lipoproteins (TRL) can be taken up by macrophages, leading to foam cell formation, probably via receptor-mediated pathways. The present study was performed to investigate whether this process is modulated by the postprandial time point at which they are collected. A meal containing refined olive oil was administered to 9 healthy young men and TRL were isolated ...

Journal: :The Journal of pharmacology and experimental therapeutics 2012
Thomas Beresford Tina Fay Natalie J Serkova Peter H Wu

High abstinence rates characterize alcohol-dependent liver graft recipients. The immunosuppressants cyclosporine A (CsA) and tacrolimus (TRL) also inhibit calcineurin (CLN) in the brain. Previously, we found that CsA reduces alcohol consumption in C57BL/6J mice. The goals of the present study were: 1) to compare the ethanol preference effects of CsA against TRL, as well as sirolimus (SRL), an i...

2004
Mark Whitsey

We present Timed Reasoning Logics (TRL) as a framework that allows one to model multiagent systems over time without assuming agents are logically omniscient. TRL can be seen as a combination of syntactic epistemic logics and temporal logics. This paper is primarily concerned with illustrating TRL concepts using a propositional natural deduction-style reasoner, which derives consequences of its...

Journal: :PloS one 2016
Marjorie Buttet Hélène Poirier Véronique Traynard Kévin Gaire Thi Thu Trang Tran Sinju Sundaresan Philippe Besnard Nada A Abumrad Isabelle Niot

The metabolic syndrome (MetS) greatly increases risk of cardiovascular disease and diabetes and is generally associated with abnormally elevated postprandial triglyceride levels. We evaluated intestinal synthesis of triglyceride-rich lipoproteins (TRL) in a mouse model of the MetS obtained by feeding a palm oil-rich high fat diet (HFD). By contrast to control mice, MetS mice secreted two popula...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه سیستان و بلوچستان 1389

در جامعه اطلاعاتی، شرکت ها نیاز به توسعه مزیت های رقابتی مبنی بر استفاده مناسب و متمرکز از فناوری های اطلاعات و ارتباطات دارند، که عاملی حیاتی برای موفقیت در بازار امروزی است. این واقعیت مخصوصاً در رابطه با شرکت های کوچک و متوسط، امری حیاتیست. از سوی دیگر، گام نخست به منظور اطمینان از پیاده سازی موثر و سودمند فناوری های اینترنت محوری چون تجارت الکترونیک در روابط کسب و کار، اندازه گیری آمادگی الک...

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