Glioblastoma multiforme is a highly aggressive brain tumor whose prognosis is very poor. Due to early invasion of brain parenchyma, its complete surgical removal is nearly impossible, and even after aggressive combined treatment (association of surgery and chemo- and radio-therapy) five-year survival is only about 10%. Natural products are sources of novel compounds endowed with therapeutic pro...

Ruta graveolens utilizes anthranilate synthase (AS) for the synthesis both of tryptophan in primary metabolism and acridone alkaloids in secondary metabolism. AS has been purified from plants and cell cultures of R. graveolens 670- and 1700-fold, respectively. Glutamine- and ammonia-dependent AS activities were strictly co-purified in all steps. Through cDNA cloning and complementation of Esche...

The Authors have studied the biosynthesis of some furocoumarins contained in Ruta graveolens. Labeled 5,7and 7,8-dihydroxycoumarins have been administered to the herb, however practically no incorporation of radioactivity was observed in the isolated furocoumarins. Moreover, with the aim to study in a more detailed way the role of rutaretin and marmesin, trapping experiments have been performed...

Suspension cultures of Rosa sp., soybean (Glycine max L.), wheat (Triticum monococcum L.), sweet clover (Melilotus alba Desc.), Haplopappus gracilis Nutt., and rue (Ruta graveolens) produced ethylene. The amount varied with the species. The rate of formation in rose and Haplopappus cells paralleled growth but accelerated when the stationary phase was reached, after which the rate declined sharp...

the antioxidant properties of ruta graveolens l. were evaluated by two different methods; free radical scavenging using dpph and inhibition of lipid peroxidation by the ferric thiocyanate method. the ic50 value of the methanol extract in dpph inhibition was 200.5 μg/ml which was acceptable in comparison with bht (41.8 μg/ml). in thiocyanate method, the plant extract demonstrated activity as muc...