Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain heavily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized b...

Salivary mucins MG1 and MG2 have been found in the oral cavity where they perform several functions such as the formation of the mucous layer covering the oral mucosa and teeth. Recent studies have demonstrated their presence in other organs and tissues. The aim of this study was to determine their expression in human bulbourethral (Cowper's) glands. Normal bulbourethral glands were obtained at...

The atomic structure of ordered domains in Ba~Mg1/3Nb2/3)O3 and La-doped and undoped Pb~Mg1/3Nb2/3)O3 is studied by high-resolution Z-contrast imaging. The ordered domain structure in both doped and undoped Pb~Mg1/3Nb2/3)O3 is determined to be in agreement with the charge balanced random-layer model and inconsistent with the space-charge model. It is shown that La doping in Pb~Mg1/3Nb2/3)O3 enh...

In radioimmunotherapy (RIT), hematologic toxicity is the dose-limiting toxicity due to the long circulatory half-life of the antibody. Although intraperitoneal (i.p.) RIT results in high uptake of i.p. growing tumors, the radiolabeled antibody enters the circulation, resulting in bone marrow toxicity. Carbohydrate modification of antibodies could induce accelerated clearance of the antibody via...

The MG1 population of mucins was isolated from human whole salivas by gel chromatography followed by isopycnic density gradient centrifugation. The reduced and alkylated MG1 mucins, separated by anion exchange chromatography, were of similar size (radius of gyration 55-64 nm) and molecular weight (2.5-2.9 x 10(6) Da). Two differently-charged populations of MG1 subunits were observed which showe...

Superconducting transition temperatures (Tc’s) of MgB2, Mg1−xCaxB2, Mg1−xNaxB2, and Mg1−xAlxB2 are studied within the McMillan approximation using electronic and structural information obtained from density functional theory within the generalized gradient approximation. The density of states and Tc of MgB2 are both shown to be extremely sensitive to volume; in fact the density of states around...

Many species of bacteria secrete natural products that inhibit the growth or development of competing species. In turn, competitors may develop or acquire resistance to antagonistic molecules. Few studies have investigated the interplay of these countervailing forces in direct competition between two species. We have used an imaging mass spectrometry (IMS) approach to track metabolites exchange...