chemistry Nitrosamines (NAs) are a family of chemical compounds discovered over 100 years ago. It was not until the 1950s that these compounds received worldwide attention. In the 1950s, two British scientists, Barnes and Magee discovered that dimethylnitrosamine is a powerful carcinogen in laboratory animals. This finding led to massive studies involving NAs in many industries throughout the y...

Synaptogenesis requires orchestrated intercellular communication between synaptic partners, with trans-synaptic signals necessarily traversing the extracellular synaptomatrix separating presynaptic and postsynaptic cells. Extracellular matrix metalloproteinases (Mmps) regulated by secreted tissue inhibitors of metalloproteinases (Timps), cleave secreted and membrane-associated targets to sculpt...