the distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. to date, the only reliable criterion is metastasis. the aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene (pttg1) and retinoblastoma (rb) in benign and malignant pheochromocytoma. paraffin blocks of 44 and 11 patients ...

A study of Rb and Rc is presented in the context of a Two Higgs Doublet Model (2HDM) with avor changing scalar currents (FCSC). Implications of the model for the -parameter and for b ! s are also considered. The experimental data on Rb places stringent constraints on the model parameters. The con guration of the model needed to account for Rb is found to be irreconcilable with constraints from ...

Graphene, a new member of the carbon family, was used as an adsorbent due to its exceptional capability to remove Rhodamine B (RB) and Malachite Green (MG), two organic dyes, from aqueous solutions. Adsorption kinetics of RB and MG onto graphene and adsorption capacity of the adsorbent were studied. Also the effects of parameters, including pH, contact time, temperature, and adsorbent dosag...

A study of Rb and Rc is presented in the context of a Two Higgs Doublet Model (2HDM) with flavor changing scalar currents (FCSC). Implications of the model for the ρ-parameter and for b → sγ are also considered. The experimental data on Rb places stringent constraints on the model parameters. The configuration of the model needed to account for Rb is found to be irreconcilable with constraints ...

The significance of p16/Rb tumor suppressor pathway inactivation in T-cell non-Hodgkin's lymphoma (NHL) remains incompletely understood. We used naturally occurring canine NHL to test the hypothesis that p16 inactivation has specific pathologic correlates. Forty-eight samples (22 T-cell NHL and 26 B-cell NHL) were included. As applicable, metaphase- or array-based comparative genomic hybridizat...

Basal-like carcinomas (BLCs) of the breast share discriminatory morphologic features with poorly differentiated high-risk human papilloma virus (HPV)-related squamous cell carcinomas of the oropharynx, penis, and vulva. Because HPV E7 protein inactivates the retinoblastoma (Rb) protein, diffuse p16 expression is a surrogate marker for these high-risk HPV-related carcinomas. HPV E6 protein also ...

Phosphorylation of the retinoblastoma protein (Rb) by the cyclin D1/cyclin-dependent kinase (cdk) 4 complex (cdk4/D1) is a key regulatory step for maintaining the orderly progression of the cell cycle. The B domain of Rb contains a site that recognizes and binds the LXCXE motif found in D-type cyclins. This interaction is important for phosphorylation of Rb by cdk4/D1, although in vitro the Rb ...