Drosophila atonal (ato) is required for the specification of founding R8 photoreceptors during retinal development. ato is regulated via dual eye-specific enhancers; ato-3' is subject to initial induction whereas 5'-ato facilitates Notch-mediated autoregulation. Notch is further utilized to induce bHLH repressors of the E(spl) locus to restrict Ato from its initial broad expression to individua...

A dramatic example of a phenotypic interaction that involves neurogenic loci during Drosophila imaginal development is the synergistic impact of split (spl), a recessive allele of the Notch locus, and E(spl)D, a dominant gain-of-function allele of the Enhancer of split locus, on morphogenesis of the compound eye. Screens for mutations that relieve the enhancing effect of E(spl)D on spl have yie...

Techniques to model software product lines (SPLs), using feature models, usually focus on a single SPL. Larger SPLs can also be built from smaller SPLs which results in a dependency between the involved SPLs, i.e., one SPL uses functionality provided by another SPL. Currently, this can be described using constraints between the involved feature models. However, if multiple differently configure...

It is accepted that noise pollution has a major impact on health, such as physical, physiological, psychological and performance related effects, all over the world. This study aims to evaluate noise pollution in four urban parks located in Sanandaj City, Iran and to zone it in GIS environment. Sound pressure level (SPL) and maximum sound level (Lmax) were measured at 45 points (each point was ...

The SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) gene family is an SBP-box transcription family in Arabidopsis. While several physiological responses to SPL genes have been reported, their biological role remains elusive. Here, we use a combined analysis of expression correlation, the interactome, and promoter content to infer the biological role of the SPL genes in Arabidopsis thaliana. Analys...

A software product line (SPL) is a set of systems that share common and varying features. To provide large-scale reuse, the components of a SPL should be easy to maintain. Therefore, developers have to identify anomalous code structures – i.e., code anomalies – that are detrimental to the SPL maintainability. Otherwise, SPL changes can eventually propagate to seemly-unrelated features and affec...

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer. S1P lyase (SPL) is the essential enzyme responsible for S1P degradation. SPL augments apoptosis and is down-regulated in cancer. SPL generates a S1P chemical gradient that promotes lymphocyte trafficking and as such is being targeted to treat autoimmune diseases. Despite growi...

Drosophila larval neurogenesis is an excellent system for studying the balance between self-renewal and differentiation of a somatic stem cell (neuroblast). Neuroblasts (NBs) give rise to differentiated neurons and glia via intermediate precursors called GMCs or INPs. We show that E(spl)mγ, E(spl)mβ, E(spl)m8 and Deadpan (Dpn), members of the basic helix-loop-helix-Orange protein family, are ex...